1 to 10 of 53 Results
Pham, Truc Lam; Zilke, Jennifer; Müller, Christine Charlotte; Thomas, Franziska, 2022, "The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]", https://doi.org/10.11588/data/ECKCUY, heiDATA, V1
This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave... |
Pham, Truc Lam; Kovermann, Michael; Thomas, Franziska, 2022, "Switchable Zinc (II)-Responsive Globular β-Sheet Peptide [Research Data]", https://doi.org/10.11588/data/HV4MJW, heiDATA, V1
The natural function of many proteins depends on their ability to switch their conformation driven by environmental changes. In this work, we present a small, monomeric β-sheet peptide that switches between a molten globule and a folded state through Zn(II) binding. The solvent-e... |
Pham, Truc Lam; Conde González, Marcos Rafael; Fazliev, Sunnatullo; Kishore, Agi; Comba, Peter; Thomas, Franziska, 2024, "Relationship of Thermostability and Binding Affinity in Metal-binding WW-Domain Minireceptors [Research Data]", https://doi.org/10.11588/data/QSJTR0, heiDATA, V1
The design of metallo-miniproteins advances our understanding of the structural and functional roles of metals in proteins. We recently designed a metal-binding WW domain, WW-CA-Nle, which displays three histidine residues on its surface for coordination of divalent metals Ni(II)... |
Kokollari, Agon; Werner, Marius; Lindner, Christina; Pham, Truc Lam; Thomas, Franziska, 2024, "Rapid On-Resin N-Formylation of Peptides as One-Pot Reaction [Research Data]", https://doi.org/10.11588/data/00RULE, heiDATA, V1
N-formylation is a common pre- and post-translational modification of the N-terminus or the lysine side chain of peptides and proteins that plays a role in the initiation of immune responses, gene expression, or epigenetics. Despite its high biological relevance, protocols for th... |
Adobe PDF - 240.5 KB -
MD5: a962e6d81fcf28f96819e56ce55d9252
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Feb 19, 2024 -
An Engineered β-Hairpin Peptide Forming Thermostable Complexes with ZnII, NiII, and CuII through a His3 Site [Research Data]
Adobe PDF - 242.1 KB -
MD5: 14c05ad5d29eb1144900e46db3cfd3b3
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Mar 24, 2022 -
The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]
Adobe PDF - 140.4 KB -
MD5: 55716e6a29e36e7ba9c0f141b01290a3
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Feb 9, 2024 -
Relationship of Thermostability and Binding Affinity in Metal-binding WW-Domain Minireceptors [Research Data]
Adobe PDF - 220.6 KB -
MD5: f73ae4f42cf2041ed0b66277137707f1
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Feb 10, 2023 -
Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data]
MS Word - 56.7 KB -
MD5: 49d945311111f593c41384958a1b107e
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Dec 19, 2022 -
Late-Stage Functionalisation of Peptides on the Solid Phase by an Iodination-Substitution Approach [Research Data]
MS Word - 55.1 KB -
MD5: d810e753f31a450093ebcb8c2e51dfe3
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