Thomas Lab

Open Research Data from the Thomas Lab at the Institute of Organic Chemistry of Heidelberg University.

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1 to 4 of 4 Results

Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data] Feb 10, 2023 Thomas, Franziska; Neitz, Hermann; Paul, Niels Benjamin; Häge, Florian; Lindner, Christina; Graebner, Roman; Kovermann, Michael, 2023, "Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data]", https://doi.org/10.11588/data/SGN2CN, heiDATA, V1 β-Sheet motifs such as the WW domain are increasingly being explored as building blocks for synthetic biological applications. Since the sequence-structure relationships of β-sheet motifs are generally complex compared to the well-studied α-helical coiled coil (CC), other approac...
Late-Stage Functionalisation of Peptides on the Solid Phase by an Iodination-Substitution Approach [Research Data] Dec 19, 2022 Werner, Marius; Pampel, Julius; Pham, Truc Lam; Thomas, Franziska, 2022, "Late-Stage Functionalisation of Peptides on the Solid Phase by an Iodination-Substitution Approach [Research Data]", https://doi.org/10.11588/data/RG2NHY, heiDATA, V1 The functionalisation of peptides at a late synthesis stage holds great potential, for example, for the synthesis of peptide pharmaceuticals, fluorescent biosensors or peptidomimetics. Here we describe an on-resin iodination-substitution reaction sequence on homoserine that is al...
The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data] Mar 24, 2022 Pham, Truc Lam; Zilke, Jennifer; Müller, Christine Charlotte; Thomas, Franziska, 2022, "The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]", https://doi.org/10.11588/data/ECKCUY, heiDATA, V1 This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave...
Switchable Zinc (II)-Responsive Globular β-Sheet Peptide [Research Data] Jan 19, 2022 Pham, Truc Lam; Kovermann, Michael; Thomas, Franziska, 2022, "Switchable Zinc (II)-Responsive Globular β-Sheet Peptide [Research Data]", https://doi.org/10.11588/data/HV4MJW, heiDATA, V1 The natural function of many proteins depends on their ability to switch their conformation driven by environmental changes. In this work, we present a small, monomeric β-sheet peptide that switches between a molten globule and a folded state through Zn(II) binding. The solvent-e...

Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data]

Feb 10, 2023

Thomas, Franziska; Neitz, Hermann; Paul, Niels Benjamin; Häge, Florian; Lindner, Christina; Graebner, Roman; Kovermann, Michael, 2023, "Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data]", https://doi.org/10.11588/data/SGN2CN, heiDATA, V1

β-Sheet motifs such as the WW domain are increasingly being explored as building blocks for synthetic biological applications. Since the sequence-structure relationships of β-sheet motifs are generally complex compared to the well-studied α-helical coiled coil (CC), other approac...

Late-Stage Functionalisation of Peptides on the Solid Phase by an Iodination-Substitution Approach [Research Data]

Dec 19, 2022

Werner, Marius; Pampel, Julius; Pham, Truc Lam; Thomas, Franziska, 2022, "Late-Stage Functionalisation of Peptides on the Solid Phase by an Iodination-Substitution Approach [Research Data]", https://doi.org/10.11588/data/RG2NHY, heiDATA, V1

The functionalisation of peptides at a late synthesis stage holds great potential, for example, for the synthesis of peptide pharmaceuticals, fluorescent biosensors or peptidomimetics. Here we describe an on-resin iodination-substitution reaction sequence on homoserine that is al...

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]

Mar 24, 2022

Pham, Truc Lam; Zilke, Jennifer; Müller, Christine Charlotte; Thomas, Franziska, 2022, "The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]", https://doi.org/10.11588/data/ECKCUY, heiDATA, V1

This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave...

Switchable Zinc (II)-Responsive Globular β-Sheet Peptide [Research Data]

Jan 19, 2022

Pham, Truc Lam; Kovermann, Michael; Thomas, Franziska, 2022, "Switchable Zinc (II)-Responsive Globular β-Sheet Peptide [Research Data]", https://doi.org/10.11588/data/HV4MJW, heiDATA, V1

The natural function of many proteins depends on their ability to switch their conformation driven by environmental changes. In this work, we present a small, monomeric β-sheet peptide that switches between a molten globule and a folded state through Zn(II) binding. The solvent-e...

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