Open Research Data from the Thomas Lab at the Institute of Organic Chemistry of Heidelberg University.
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Mar 24, 2022
Pham, Truc Lam; Zilke, Jennifer; Müller, Christine Charlotte; Thomas, Franziska, 2022, "The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]",, heiDATA, V1
This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave...
Jan 19, 2022
Pham, Truc Lam; Kovermann, Michael; Thomas, Franziska, 2022, "Switchable Zinc (II)-Responsive Globular β-Sheet Peptide [Research Data]",, heiDATA, V1
The natural function of many proteins depends on their ability to switch their conformation driven by environmental changes. In this work, we present a small, monomeric β-sheet peptide that switches between a molten globule and a folded state through Zn(II) binding. The solvent-e...
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