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Translation initiation factor eIF3m controls ubiquitination-dependent early elongation pausing of ribosomes
Translation initiation factor eIF3m controls ubiquitination-dependent early elongation pausing of ribosomes
Feb 20, 2023
Reitter, Sonja; Schoelz, Christian; Stoecklin, Georg, 2023, "Translation initiation factor eIF3m controls ubiquitination-dependent early elongation pausing of ribosomes", https://doi.org/10.11588/data/M5ZUPP, heiDATA, V1
While translation initiation is extensively regulated, fewer mechanisms are known to control translation elongation. We discovered that prolonged stimulation of macrophages leads to suppression of protein synthesis at the level of translation elongation, through pausing of riboso...
Image-based screening for stress granule regulators
Jan 7, 2021
Eiermann, Nina; Stoecklin, Georg, 2021, "Image-based screening for stress granule regulators", https://doi.org/10.11588/data/KRPJ9A, heiDATA, V1
The supplied macro provides the opportunity to analyse large-scale image datasets, derived from image-based screening approaches. It can be used as a base for the segmentation of individual cells, referred as regions of interest (ROIs), and the detection and quantification of the...
CDK1 couples proliferation with protein synthesis [Repository Tables R1-R4]
Feb 6, 2020 - SFB 1036
Haneke, Katharina; Stoecklin, Georg, 2020, "CDK1 couples proliferation with protein synthesis [Repository Tables R1-R4]", https://doi.org/10.11588/data/EFHOBZ, heiDATA, V1, UNF:6:+D39RBZQyWVzfn6Sv1nj+w== [fileUNF]
Cell proliferation exerts a high demand on protein synthesis, yet the mechanisms coupling the two processes are not fully understood. A kinase and phosphatase screen for activators of translation, based on the formation of stress granules in human cells, revealed cell cycle-assoc...
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