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Jun 1, 2023 - HITS MBM
Gräter, Frauke; Franz, Florian; Winograd-Katz, Sabina; Tapia-Rojo, Rafael; Boujemaa-Paterski, Rajaa; Li, Wenhong; Unger, Tamar; Albeck, Shira; Aponte-Santamaria, Camilo; Garcia-Manyes, Sergi; Medalia, Ohad; Geiger, Benny, 2023, "Allosteric Activation of Vinculin by Talin [data]", https://doi.org/10.11588/data/WZDKT6, heiDATA, V1, UNF:6:32j0OWUdxRAbsyCMzwdFcQ== [fileUNF]
The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule magnetic tweezer experiments, Molecular Dynamics simulations, actin bundling assa... |
Feb 15, 2023 - HITS MBM
Buhr, Jannik; Franz, Florian; Gräter, Frauke, 2023, "Intrinsically disordered region of talin’s FERM domain functions as an initial PIP2 recognition site [research data]", https://doi.org/10.11588/data/BQTQUN, heiDATA, V1
Focal adhesions (FAs) mediate the interaction of the cytoskeleton with the extracellular matrix (ECM) in a highly dynamic fashion. talin is a central regulator, adaptor protein and mechano-sensor of focal adhesion complexes. For recruitment and firm attachment at FAs, talin’s N-t... |