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Subject: Physics Subject: Medicine, Health and Life Sciences

1 to 10 of 14 Results

Allosteric Activation of Vinculin by Talin [data] Jun 1, 2023 - HITS MBM Gräter, Frauke; Franz, Florian; Winograd-Katz, Sabina; Tapia-Rojo, Rafael; Boujemaa-Paterski, Rajaa; Li, Wenhong; Unger, Tamar; Albeck, Shira; Aponte-Santamaria, Camilo; Garcia-Manyes, Sergi; Medalia, Ohad; Geiger, Benny, 2023, "Allosteric Activation of Vinculin by Talin [data]", https://doi.org/10.11588/data/WZDKT6, heiDATA, V1, UNF:6:32j0OWUdxRAbsyCMzwdFcQ== [fileUNF] The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule magnetic tweezer experiments, Molecular Dynamics simulations, actin bundling assa...
Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data] Mar 24, 2023 - HITS MBM Rennekamp, Benedikt; Gräter, Frauke, 2023, "Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]", https://doi.org/10.11588/data/HJ6SVM, heiDATA, V1, UNF:6:Da6omTKjrSvNcDwyJxuHOg== [fileUNF] This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related pu...
Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset] Oct 16, 2014 - Theoretical Physics Jerabek, Hansjörg; Tark-Dame, Mariliis; Manders, Erik M. M.; Heermann, Dieter W.; van Driel, Roel, 2014, "Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]", https://doi.org/10.11588/data/10028, heiDATA, V4 Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.
Dose Enhancement Effects of Gold Nanoparticles Specifically Targeting RNA in Breast Cancer Cells [Dataset] Dec 4, 2017 - Experimental Biophysics Hildenbrand, Georg; Metzler, Philipp; Pilarczyk, Goetz; Bobu, Vladimir; Hosser, Hiltraud; Fleckenstein, Jens; Krufczik, Matthias; Bestvater, Felix; Wenz, Frederik; Hausmann, Michael, 2017, "Dose Enhancement Effects of Gold Nanoparticles Specifically Targeting RNA in Breast Cancer Cells [Dataset]", https://doi.org/10.11588/data/N8NHE2, heiDATA, V1 Localization microscopy has shown to be capable of systematic investigations on the arrangement and counting of cellular uptake of gold nanoparticles (GNP) with nanometer resolution. In this article, we show that the application of specially modified RNA targeting gold nanopartic...
Experimental Biophysics(Heidelberg University - Kirchhoff-Institute for Physics) May 19, 2015 This Dataverse contains research data of the Kirchhoff-Institute for Physics at Heidelberg University.
Göpfrich Group - Biophysical Engineering of Life(Cluster of Excellence "3D Matter Made to Order" and MPI for Medical Research) Nov 30, 2021 The Göpfrich Group is located at at the Max Planck Institute for Medical Research and part of the Cluster of Excellence "3D Matter Made to Order".
HITS MBM(Heidelberg Institute for Theoretical Studies) Nov 8, 2022 Data publications from the the Molecular Biomechanics (MBM) group at HITS. Shareholders of HITS are the “HITS-Stiftung”, Heidelberg University and the Karlsruhe Institute of Technology (KIT)
Inter-Nucleosomal Potentials from Nucleosomal Positioning Data [Research Data] Mar 29, 2022 - Theoretical Physics Li, Kunhe; Oiwa, Nestor N.; Mishra, Sujeet K.; Heermann, Dieter W., 2022, "Inter-Nucleosomal Potentials from Nucleosomal Positioning Data [Research Data]", https://doi.org/10.11588/data/H3KPEU, heiDATA, V1 This dataset accompanies the paper "Inter-Nucleosomal Potentials from Nucleosomal Positioning Data." In this paper, a systematic method to develop inter-nucleosomal potentials between nucleosomes along a chromosome is focused. To this purpose, a modified Lennard-Jones potential i...
Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data] Dec 4, 2023 - HITS MBM Roessner Rita; Michelarakis, Nicholas; Gräter, Frauke; Aponte-Santamaría, Camilo, 2023, "Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data]", https://doi.org/10.11588/data/EZHMDU, heiDATA, V1 Plasmodium falciparum (Pf) is responsible for the most lethal form of malaria. VAR2CSA is an adhesin protein expressed by this parasite at the membrane of infected erythrocytes for attachment to the placenta, leading to pregnancy-associated malaria. VAR2CSA is a large 355 kDa mul...
Prediction and Comparative Analysis of CTCF Binding Sites based on a First Principle Approach [Research Data] Mar 7, 2022 - Theoretical Physics Li, Kunhe; Oiwa, Nestor Norio; Cordeiro, Claudette E.; Heermann, Dieter W., 2022, "Prediction and Comparative Analysis of CTCF Binding Sites based on a First Principle Approach [Research Data]", https://doi.org/10.11588/data/RDISCE, heiDATA, V1 The file contains the CTCF-DNA binding sites for complete genome of Homo sapiens (human), Mus musculus (mouse), Sus scrofa (pig), Capra hircus (goat), Aedes aegypti (dengue and yellow fever mosquito) and Drosophila melanogaster (fruit fly) using electronic nucleotide alignment. T...

Allosteric Activation of Vinculin by Talin [data]

Jun 1, 2023 - HITS MBM

Gräter, Frauke; Franz, Florian; Winograd-Katz, Sabina; Tapia-Rojo, Rafael; Boujemaa-Paterski, Rajaa; Li, Wenhong; Unger, Tamar; Albeck, Shira; Aponte-Santamaria, Camilo; Garcia-Manyes, Sergi; Medalia, Ohad; Geiger, Benny, 2023, "Allosteric Activation of Vinculin by Talin [data]", https://doi.org/10.11588/data/WZDKT6, heiDATA, V1, UNF:6:32j0OWUdxRAbsyCMzwdFcQ== [fileUNF]

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule magnetic tweezer experiments, Molecular Dynamics simulations, actin bundling assa...

Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]

Mar 24, 2023 - HITS MBM

Rennekamp, Benedikt; Gräter, Frauke, 2023, "Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]", https://doi.org/10.11588/data/HJ6SVM, heiDATA, V1, UNF:6:Da6omTKjrSvNcDwyJxuHOg== [fileUNF]

This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related pu...

Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]

Oct 16, 2014 - Theoretical Physics

Jerabek, Hansjörg; Tark-Dame, Mariliis; Manders, Erik M. M.; Heermann, Dieter W.; van Driel, Roel, 2014, "Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]", https://doi.org/10.11588/data/10028, heiDATA, V4

Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.

Dose Enhancement Effects of Gold Nanoparticles Specifically Targeting RNA in Breast Cancer Cells [Dataset]

Dec 4, 2017 - Experimental Biophysics

Hildenbrand, Georg; Metzler, Philipp; Pilarczyk, Goetz; Bobu, Vladimir; Hosser, Hiltraud; Fleckenstein, Jens; Krufczik, Matthias; Bestvater, Felix; Wenz, Frederik; Hausmann, Michael, 2017, "Dose Enhancement Effects of Gold Nanoparticles Specifically Targeting RNA in Breast Cancer Cells [Dataset]", https://doi.org/10.11588/data/N8NHE2, heiDATA, V1

Localization microscopy has shown to be capable of systematic investigations on the arrangement and counting of cellular uptake of gold nanoparticles (GNP) with nanometer resolution. In this article, we show that the application of specially modified RNA targeting gold nanopartic...

Experimental Biophysics(Heidelberg University - Kirchhoff-Institute for Physics)

May 19, 2015

This Dataverse contains research data of the Kirchhoff-Institute for Physics at Heidelberg University.

Göpfrich Group - Biophysical Engineering of Life(Cluster of Excellence "3D Matter Made to Order" and MPI for Medical Research)

Nov 30, 2021

The Göpfrich Group is located at at the Max Planck Institute for Medical Research and part of the Cluster of Excellence "3D Matter Made to Order".

HITS MBM(Heidelberg Institute for Theoretical Studies)

Nov 8, 2022

Data publications from the the Molecular Biomechanics (MBM) group at HITS. Shareholders of HITS are the “HITS-Stiftung”, Heidelberg University and the Karlsruhe Institute of Technology (KIT)

Inter-Nucleosomal Potentials from Nucleosomal Positioning Data [Research Data]

Mar 29, 2022 - Theoretical Physics

Li, Kunhe; Oiwa, Nestor N.; Mishra, Sujeet K.; Heermann, Dieter W., 2022, "Inter-Nucleosomal Potentials from Nucleosomal Positioning Data [Research Data]", https://doi.org/10.11588/data/H3KPEU, heiDATA, V1

This dataset accompanies the paper "Inter-Nucleosomal Potentials from Nucleosomal Positioning Data." In this paper, a systematic method to develop inter-nucleosomal potentials between nucleosomes along a chromosome is focused. To this purpose, a modified Lennard-Jones potential i...

Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data]

Dec 4, 2023 - HITS MBM

Roessner Rita; Michelarakis, Nicholas; Gräter, Frauke; Aponte-Santamaría, Camilo, 2023, "Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data]", https://doi.org/10.11588/data/EZHMDU, heiDATA, V1

Plasmodium falciparum (Pf) is responsible for the most lethal form of malaria. VAR2CSA is an adhesin protein expressed by this parasite at the membrane of infected erythrocytes for attachment to the placenta, leading to pregnancy-associated malaria. VAR2CSA is a large 355 kDa mul...

Prediction and Comparative Analysis of CTCF Binding Sites based on a First Principle Approach [Research Data]

Mar 7, 2022 - Theoretical Physics

Li, Kunhe; Oiwa, Nestor Norio; Cordeiro, Claudette E.; Heermann, Dieter W., 2022, "Prediction and Comparative Analysis of CTCF Binding Sites based on a First Principle Approach [Research Data]", https://doi.org/10.11588/data/RDISCE, heiDATA, V1

The file contains the CTCF-DNA binding sites for complete genome of Homo sapiens (human), Mus musculus (mouse), Sus scrofa (pig), Capra hircus (goat), Aedes aegypti (dengue and yellow fever mosquito) and Drosophila melanogaster (fruit fly) using electronic nucleotide alignment. T...

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