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Subject: Medicine, Health and Life Sciences

21 to 30 of 109 Results

Diagnostic performance of host protein signatures as a triage test for active pulmonary TB [data] Sep 21, 2023 - Division of Infectious Disease and Tropical Medicine FIND, Geneva, Switzerland, 2023, "Diagnostic performance of host protein signatures as a triage test for active pulmonary TB [data]", https://doi.org/10.11588/data/CYYNBA, heiDATA, V1 The current four symptom screen recommended by the WHO is widely used as screen to initiate diagnostic testing for active pulmonary tuberculosis (TB), yet the performance is poor especially when TB prevalence is low. In contrast, more sensitive molecular tests are less suitable f...
Accurate classification of major brain cell types using in vivo imaging and neural network processing Sep 18, 2023 - Functional Neuroanatomy Johannes Knabbe, 2023, "Accurate classification of major brain cell types using in vivo imaging and neural network processing", https://doi.org/10.11588/data/L3PITA, heiDATA, V1, UNF:6:j36lvBMAVhENUbq1px2P/Q== [fileUNF] This dataset accompanies the article of the same title in the journal Plos Biology. It includes a) Ground truth datasets for the training of the StarDist neuronal network for nucleus segmentation (StardistTraining.tar.gz) b) The trained Stardist nucleus segmentation model (Stardi...
Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results] Sep 18, 2023 - Forschungsgruppe AG Nikendei Kindermann, David; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Nikendei, Christoph, 2023, "Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results]", https://doi.org/10.11588/data/MYFILV, heiDATA, V4 Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy). We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.
German funders' data sharing policies - A qualitative interview study [interview excerpts] Aug 15, 2023 - NCT - Section of Translational Medical Ethics Anger, Michael; Wendelborn, Christian; Schickhardt, Christoph, 2023, "German funders' data sharing policies - A qualitative interview study [interview excerpts]", https://doi.org/10.11588/data/FJAG0X, heiDATA, V1 Background Data sharing is commonly seen as beneficial for science, but is not yet common practice. Research funding agencies are known to play a key role in promoting data sharing, but German funders’ data sharing policies appear to lag behind in international comparison. This s...
Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis] Jul 28, 2023 - Forschungsgruppe AG Nikendei Nowak, Jonathan; Nikendei, Christoph; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Kindermann, David, 2023, "Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis]", https://doi.org/10.11588/data/AJKTKU, heiDATA, V1 This dataset contains the complete analysis and results which were conducted for the study 'Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders' within one RMarkdown-Sheet.
Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data] Jul 7, 2023 - AG Computational Diagnostic Kriegsmann, Mark; Kriegsmann, Katharina; Steinbuss, Georg; Zgorzelski, Christiane; Albrecht, Thomas; Heinrich, Stefan; Farkas, Stefan; Roth, Wilfried; Hausen, Anne; Gaida, Matthias M., 2023, "Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data]", https://doi.org/10.11588/data/YAZWJW, heiDATA, V1, UNF:6:gpQyF/jPYXHbW7GvjUboGQ== [fileUNF] Differentiation of neoplastic and non-neoplastic liver lesions using routine histological tissue sections can be challenging. Correct classification is paramount to forecast prognosis and to select the correct therapy. Deep learning algorithms have recently been suggested to supp...
Allosteric Activation of Vinculin by Talin [data] Jun 1, 2023 - HITS MBM Gräter, Frauke; Franz, Florian; Winograd-Katz, Sabina; Tapia-Rojo, Rafael; Boujemaa-Paterski, Rajaa; Li, Wenhong; Unger, Tamar; Albeck, Shira; Aponte-Santamaria, Camilo; Garcia-Manyes, Sergi; Medalia, Ohad; Geiger, Benny, 2023, "Allosteric Activation of Vinculin by Talin [data]", https://doi.org/10.11588/data/WZDKT6, heiDATA, V1, UNF:6:32j0OWUdxRAbsyCMzwdFcQ== [fileUNF] The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule magnetic tweezer experiments, Molecular Dynamics simulations, actin bundling assa...
Primary Somatosensory Cortex Bidirectionally Modulates Sensory Gain and Nociceptive Behavior in a Layer-Specific Manner [Research Data] May 26, 2023 - Medical Biophysics Group Ziegler, Katharina; Folkard, Ross; Gonzalez, Antonio; Burghardt, Jan; Antharvedi-Goda, Sailaja; Martín-Cortecero, Jesús; Isaías-Camacho, Emilio; Kaushalya, Sanjeev; Tan, Linette Liqi; Kuner, Thomas; Acuna, Claudio; Kuner, Rohini; Mease, Rebecca; Groh, Alexander, 2023, "Primary Somatosensory Cortex Bidirectionally Modulates Sensory Gain and Nociceptive Behavior in a Layer-Specific Manner [Research Data]", https://doi.org/10.11588/data/D2O0JZ, heiDATA, V2 This dataset contains electrophysiological and behavioral data and codes underlying the figures in Ziegler, K., Folkard, R., Gonzalez, A.J. et al. Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner. Nat Commun 1...
Affectionate touch and diurnal oxytocin levels: An ecological momentary assessment study [Research Data] May 16, 2023 - Institute of Medical Psychology Schneider, Ekaterina; Hopf, Dora; Beate Ditzen, 2023, "Affectionate touch and diurnal oxytocin levels: An ecological momentary assessment study [Research Data]", https://doi.org/10.11588/data/WFNWJT, heiDATA, V1, UNF:6:sdjqNLtCHLy4gsSjmLEFfg== [fileUNF] Abstract: Affectionate touch, which is vital for mental and physical health, was restricted during the Covid-19 pandemic. This study investigated the association between momentary affectionate touch and subjective well-being, as well as salivary oxytocin and cortisol in everyday...
ARPC5 Isoforms and Their Regulation by Calcium-Cal 1 modulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells [Source Data Files] May 9, 2023 - Integrative Virology Sadhu, Lopamudra; Tsopoulidis, Nikolaos; Hasanuzzaman, Md; Laket, Vibor; Way, Michael; Fackler, Oliver T., 2023, "ARPC5 Isoforms and Their Regulation by Calcium-Cal 1 modulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells [Source Data Files]", https://doi.org/10.11588/data/YVYEO8, heiDATA, V2 This dataset contains the source data files of the article 'ARPC5 Isoforms and Their Regulation by Calcium-Cal 1 modulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells' by Sadhu et al. pulished in eLife.

Diagnostic performance of host protein signatures as a triage test for active pulmonary TB [data]

Sep 21, 2023 - Division of Infectious Disease and Tropical Medicine

FIND, Geneva, Switzerland, 2023, "Diagnostic performance of host protein signatures as a triage test for active pulmonary TB [data]", https://doi.org/10.11588/data/CYYNBA, heiDATA, V1

The current four symptom screen recommended by the WHO is widely used as screen to initiate diagnostic testing for active pulmonary tuberculosis (TB), yet the performance is poor especially when TB prevalence is low. In contrast, more sensitive molecular tests are less suitable f...

Accurate classification of major brain cell types using in vivo imaging and neural network processing

Sep 18, 2023 - Functional Neuroanatomy

Johannes Knabbe, 2023, "Accurate classification of major brain cell types using in vivo imaging and neural network processing", https://doi.org/10.11588/data/L3PITA, heiDATA, V1, UNF:6:j36lvBMAVhENUbq1px2P/Q== [fileUNF]

This dataset accompanies the article of the same title in the journal Plos Biology. It includes a) Ground truth datasets for the training of the StarDist neuronal network for nucleus segmentation (StardistTraining.tar.gz) b) The trained Stardist nucleus segmentation model (Stardi...

Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results]

Sep 18, 2023 - Forschungsgruppe AG Nikendei

Kindermann, David; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Nikendei, Christoph, 2023, "Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results]", https://doi.org/10.11588/data/MYFILV, heiDATA, V4

Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy). We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.

German funders' data sharing policies - A qualitative interview study [interview excerpts]

Aug 15, 2023 - NCT - Section of Translational Medical Ethics

Anger, Michael; Wendelborn, Christian; Schickhardt, Christoph, 2023, "German funders' data sharing policies - A qualitative interview study [interview excerpts]", https://doi.org/10.11588/data/FJAG0X, heiDATA, V1

Background Data sharing is commonly seen as beneficial for science, but is not yet common practice. Research funding agencies are known to play a key role in promoting data sharing, but German funders’ data sharing policies appear to lag behind in international comparison. This s...

Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis]

Jul 28, 2023 - Forschungsgruppe AG Nikendei

Nowak, Jonathan; Nikendei, Christoph; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Kindermann, David, 2023, "Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis]", https://doi.org/10.11588/data/AJKTKU, heiDATA, V1

This dataset contains the complete analysis and results which were conducted for the study 'Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders' within one RMarkdown-Sheet.

Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data]

Jul 7, 2023 - AG Computational Diagnostic

Kriegsmann, Mark; Kriegsmann, Katharina; Steinbuss, Georg; Zgorzelski, Christiane; Albrecht, Thomas; Heinrich, Stefan; Farkas, Stefan; Roth, Wilfried; Hausen, Anne; Gaida, Matthias M., 2023, "Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data]", https://doi.org/10.11588/data/YAZWJW, heiDATA, V1, UNF:6:gpQyF/jPYXHbW7GvjUboGQ== [fileUNF]

Differentiation of neoplastic and non-neoplastic liver lesions using routine histological tissue sections can be challenging. Correct classification is paramount to forecast prognosis and to select the correct therapy. Deep learning algorithms have recently been suggested to supp...

Allosteric Activation of Vinculin by Talin [data]

Jun 1, 2023 - HITS MBM

Gräter, Frauke; Franz, Florian; Winograd-Katz, Sabina; Tapia-Rojo, Rafael; Boujemaa-Paterski, Rajaa; Li, Wenhong; Unger, Tamar; Albeck, Shira; Aponte-Santamaria, Camilo; Garcia-Manyes, Sergi; Medalia, Ohad; Geiger, Benny, 2023, "Allosteric Activation of Vinculin by Talin [data]", https://doi.org/10.11588/data/WZDKT6, heiDATA, V1, UNF:6:32j0OWUdxRAbsyCMzwdFcQ== [fileUNF]

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule magnetic tweezer experiments, Molecular Dynamics simulations, actin bundling assa...

Primary Somatosensory Cortex Bidirectionally Modulates Sensory Gain and Nociceptive Behavior in a Layer-Specific Manner [Research Data]

May 26, 2023 - Medical Biophysics Group

Ziegler, Katharina; Folkard, Ross; Gonzalez, Antonio; Burghardt, Jan; Antharvedi-Goda, Sailaja; Martín-Cortecero, Jesús; Isaías-Camacho, Emilio; Kaushalya, Sanjeev; Tan, Linette Liqi; Kuner, Thomas; Acuna, Claudio; Kuner, Rohini; Mease, Rebecca; Groh, Alexander, 2023, "Primary Somatosensory Cortex Bidirectionally Modulates Sensory Gain and Nociceptive Behavior in a Layer-Specific Manner [Research Data]", https://doi.org/10.11588/data/D2O0JZ, heiDATA, V2

This dataset contains electrophysiological and behavioral data and codes underlying the figures in Ziegler, K., Folkard, R., Gonzalez, A.J. et al. Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner. Nat Commun 1...

Affectionate touch and diurnal oxytocin levels: An ecological momentary assessment study [Research Data]

May 16, 2023 - Institute of Medical Psychology

Schneider, Ekaterina; Hopf, Dora; Beate Ditzen, 2023, "Affectionate touch and diurnal oxytocin levels: An ecological momentary assessment study [Research Data]", https://doi.org/10.11588/data/WFNWJT, heiDATA, V1, UNF:6:sdjqNLtCHLy4gsSjmLEFfg== [fileUNF]

Abstract: Affectionate touch, which is vital for mental and physical health, was restricted during the Covid-19 pandemic. This study investigated the association between momentary affectionate touch and subjective well-being, as well as salivary oxytocin and cortisol in everyday...

ARPC5 Isoforms and Their Regulation by Calcium-Cal 1 modulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells [Source Data Files]

May 9, 2023 - Integrative Virology

Sadhu, Lopamudra; Tsopoulidis, Nikolaos; Hasanuzzaman, Md; Laket, Vibor; Way, Michael; Fackler, Oliver T., 2023, "ARPC5 Isoforms and Their Regulation by Calcium-Cal 1 modulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells [Source Data Files]", https://doi.org/10.11588/data/YVYEO8, heiDATA, V2

This dataset contains the source data files of the article 'ARPC5 Isoforms and Their Regulation by Calcium-Cal 1 modulin-N-WASP Drive Distinct Arp2/3-dependent Actin Remodeling Events in CD4 T Cells' by Sadhu et al. pulished in eLife.

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