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1 to 10 of 23 Results
Illig, Maja; Jahnke, Kevin; Weise, Lukas P.; Scheffold, Marlene; Mersdorf, Ulrike; Drechsler, Hauke; Zhang, Yixin; Diez, Stefan; Kierfeld, Jan; Göpfrich, Kerstin, 2024, "Triggered contraction of self-assembled micron-scale DNA nanotube rings [Research Data]", https://doi.org/10.11588/data/ADYUNN, heiDATA, V1, UNF:6:AJdXI51lTUqvs4V/XCVPZQ== [fileUNF]
Contractile rings formed from cytoskeletal filaments mediate the division of cells. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes as mimics of cytoskeletal filaments and a... |
Pham, Truc Lam; Zilke, Jennifer; Müller, Christine Charlotte; Thomas, Franziska, 2022, "The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides [Research Data]", https://doi.org/10.11588/data/ECKCUY, heiDATA, V1
This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave... |
Dec 7, 2023 - HITS MBM
Riedmiller, Kai; Reiser, Patrick; Bobkova, Elizaveta; Maltsev, Kiril; Gryn’ova, Ganna; Friederich, Pascal; Gräter, Frauke, 2023, "Substituting density functional theory in reaction barrier calculations for hydrogen atom transfer in proteins [data]", https://doi.org/10.11588/data/TGDD4Y, heiDATA, V2
Hydrogen atom transfer (HAT) reactions are important in many biological systems. As these reactions are hard to observe experimentally, it is of high interest to shed light on them using simulations. Here, we present a machine learning model based on graph neural networks for the... |
Feb 6, 2023 - Bunz Group
Maier, Steffen, 2023, "Substituted Cyclopentannulated Tetraazapentacenes [data]", https://doi.org/10.11588/data/AUTKBW, heiDATA, V1
Brominated pentannulated dihydrotetraazapentacenes were prepared by gold- or palladium-catalyzed 5-endo-dig cyclization of TIPS-ethynylated dihydrotetraazaacenes (TIPS = triisopropylsilyl). Post-functionalization was demonstrated by Sonogashira alkynylation and Rosenmund-von Brau... |
Jan 17, 2022 - Institute of Organic Chemistry - AK Mastalerz
Holsten, Mattes; Feierabend, Sarah; Elbert, Sven M.; Rominger, Frank; Oeser, Thomas; Mastalerz, Michael, 2022, "Soluble Congeners of Prior Insoluble Shape‐Persistent Imine Cages [Data]", https://doi.org/10.11588/data/E2RPGA, heiDATA, V1
One of the most applied reaction types to synthesize shape‐persistent organic cage compounds is the imine condensation reaction and it is assumed that the formed cages are thermodynamically controlled products due to the reversibility of the imine condensation. However, most of t... |
Aug 23, 2023 - Institute of Organic Chemistry - AK Mastalerz
Holsten, Mattes; Elbert, Sven Michael; Rominger, Frank; Zhang, Wen-Shan; Schröder, Rasmus R.; Mastalerz, Michael, 2023, "Single Crystals of Insoluble Porous Salicylimine Cages [Data]", https://doi.org/10.11588/data/45FZRY, heiDATA, V1
Porous organic cages (POCs) are meanwhile an established class of porous materials. Most of them are soluble to a certain extend and thus processable in or from solution. However, a few of larger salicylimine cages were reported to be insoluble in any organic solvents and thus ch... |
Kokollari, Agon; Werner, Marius; Lindner, Christina; Pham, Truc Lam; Thomas, Franziska, 2024, "Rapid On-Resin N-Formylation of Peptides as One-Pot Reaction [Research Data]", https://doi.org/10.11588/data/00RULE, heiDATA, V1
N-formylation is a common pre- and post-translational modification of the N-terminus or the lysine side chain of peptides and proteins that plays a role in the initiation of immune responses, gene expression, or epigenetics. Despite its high biological relevance, protocols for th... |
Mar 4, 2024 - 3D Matter Made to Order (3DMM2O)
Catt, Samantha; Hackner, Maximillian; Spatz, Joachim P.; Blasco, Eva, 2024, "Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures [data]", https://doi.org/10.11588/data/T2SJZC, heiDATA, V1
Macromolecules with complex, defined structures exist in nature but rarely is this degree of control afforded in synthetic macromolecules. Sequence-defined approaches provide a solution for precise control of the primary macromolecular structure. Despite a growing interest, very... |
Dec 19, 2022 - Thomas Lab
Werner, Marius; Pampel, Julius; Pham, Truc Lam; Thomas, Franziska, 2022, "Late-Stage Functionalisation of Peptides on the Solid Phase by an Iodination-Substitution Approach [Research Data]", https://doi.org/10.11588/data/RG2NHY, heiDATA, V1
The functionalisation of peptides at a late synthesis stage holds great potential, for example, for the synthesis of peptide pharmaceuticals, fluorescent biosensors or peptidomimetics. Here we describe an on-resin iodination-substitution reaction sequence on homoserine that is al... |
Apr 16, 2024 - SFB 1249: N-Heteropolyzyklen als Funktionsmaterialien - B: Theory & Structure
Dreuw, Andreas; Tegeder, Petra, 2024, "Influence of N-introduction on the electronic structure and properties of polyacenes: experiment and quantum chemistry in concert [research data]", https://doi.org/10.11588/data/FEQZX9, heiDATA, V1
N-Heteropolycycles (NHPCs) represent a promising substance class for applications in functional organic materials, since their electronic structure and the resulting individual molecular properties are efficiently tuneable by number and position of nitrogen atoms in the aromatic... |
