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Apr 6, 2020 - Anders Group
Roider, Tobias; Seufert, Julian; Uvarovskii, Alexey; Frauhammer, Felix; Bordas, Marie; Abedpour, Nima; Stolarczyk, Marta; Mallm, Jan-Philipp; Herbst, Sophie A.; Bruch, Peter-Martin; Balke-Want, Hyatt; Hundemer, Michael; Rippe, Karsten; Goeppert, Benjamin; Seiffert, Martina; Brors, Benedikt; Mechtersheimer, Gunhild; Zenz, Thorsten; Peifer, Martin; Chapuy, Björn; Schlesner, Matthias; Müller-Tidow, Carsten; Fröhling, Stefan; Huber, Wolfgang; Anders, Simon; Sascha Dietrich, 2020, "Dissecting intratumor heterogeneity of nodal B cell lymphomas at transcriptional, genetic, and drug response levels", https://doi.org/10.11588/data/VRJUNV, heiDATA, V1, UNF:6:AlKw3YwYZ82Ty5CxnC4D5w== [fileUNF]
Tumour heterogeneity encompasses both the malignant cells and their microenvironment. While heterogeneity between individual patients is known to affect the efficacy of cancer therapy, most personalized treatment approaches do not account for intratumor heterogeneity. We addresse... |
Nov 27, 2018 - Diagnostic and Interventional Radiology
Triphan, Simon, 2018, "Perfusion quantification data for "Towards Quantitative Perfusion MRI of the Lung in COPD: The Problem of Short-Term Repeatability"", https://doi.org/10.11588/data/ZPEZPX, heiDATA, V1, UNF:6:SE0iKbhWdsMOrcUkd706AA== [fileUNF]
ABSTRACT Purpose 4D perfusion magnetic resonance imaging (MRI) with intravenous injection of contrast agent allows for a radiation-free assessment of regional lung function. It is therefore a valuable method to monitor response to treatment in patients with chronic obstructive pu... |
Kabisch, Maria; Hamann, Ute; Lorenzo Bermejo, Justo, 2018, "Imputation of Missing Genotypes within LD-Blocks Relying on the Basic Coalescent and Beyond [Source Code]", https://doi.org/10.11588/data/X9UEHB, heiDATA, V1
Background Genotypes not directly measured in genetic studies are often imputed to improve statistical power and to increase mapping resolution. The accuracy of standard imputation techniques strongly depends on the similarity of linkage disequilibrium (LD) patterns in the study... |
Peil, Barbara; Kabisch, Maria; Fischer, Christine; Hamann, Ute; Lorenzo Bermejo, Justo, 2018, "Tailored Selection of Study Individuals to be Sequenced in Order to Improve the Accuracy of Genotype Imputation [Source Code]", https://doi.org/10.11588/data/TT4VM3, heiDATA, V1
The addition of sequence data from own‐study individuals to genotypes from external data repositories, for example, the HapMap, has been shown to improve the accuracy of imputed genotypes. Early approaches for reference panel selection favored individuals who best reflect recombi... |
Cleo-Aron Weis, 2018, "Histopathology of thymectomy specimens from the MGTX-trial", https://doi.org/10.11588/data/NWE2JJ, heiDATA, V1, UNF:6:Od2UlnHG3ctanb4ikzIx4g== [fileUNF]
Background: The thymectomy specimens from the “thymectomy trial in non-thymomatous myasthenia gravis patients receiving prednisone therapy” (MGTX) [1] underwent rigid and comprehensive work-up, which results in a unique, spatially mapped dataset. Fig. 1 Specimen work-up: Work-up... |
