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Subject: Medicine, Health and Life Sciences Publication Year: 2023

11 to 20 of 35 Results

Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data] Dec 4, 2023 - HITS MBM Roessner Rita; Michelarakis, Nicholas; Gräter, Frauke; Aponte-Santamaría, Camilo, 2023, "Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data]", https://doi.org/10.11588/data/EZHMDU, heiDATA, V1 Plasmodium falciparum (Pf) is responsible for the most lethal form of malaria. VAR2CSA is an adhesin protein expressed by this parasite at the membrane of infected erythrocytes for attachment to the placenta, leading to pregnancy-associated malaria. VAR2CSA is a large 355 kDa mul...
Koordinierungszentrum für Klinische Studien(Medizinische Fakultät der Universität Heidelberg und Universitätsklinikum Heidelberg) Apr 19, 2023 Open-Data-Veröffentlichungen des Koordinierungszentrums für Klinische Studien am Universitätsklinikum Heidelberg und der medizinischen Fakultät Heidelberg.
Intrinsically disordered region of talin’s FERM domain functions as an initial PIP2 recognition site [research data] Feb 15, 2023 - HITS MBM Buhr, Jannik; Franz, Florian; Gräter, Frauke, 2023, "Intrinsically disordered region of talin’s FERM domain functions as an initial PIP2 recognition site [research data]", https://doi.org/10.11588/data/BQTQUN, heiDATA, V1 Focal adhesions (FAs) mediate the interaction of the cytoskeleton with the extracellular matrix (ECM) in a highly dynamic fashion. talin is a central regulator, adaptor protein and mechano-sensor of focal adhesion complexes. For recruitment and firm attachment at FAs, talin’s N-t...
Integrative Virology(Center for Integrative Infectious Diseases Research (CIID), Heidelberg University Hospital) Apr 18, 2023 The Center for Integrative Infectious Diseases Research is a state-of-the art research facility of the Department for Infectious Diseases at the University Hospital Heidelberg. Our mission is to define pathogenic principles of major human pathogens and to translate these findings...
Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data] Jul 7, 2023 - AG Computational Diagnostic Kriegsmann, Mark; Kriegsmann, Katharina; Steinbuss, Georg; Zgorzelski, Christiane; Albrecht, Thomas; Heinrich, Stefan; Farkas, Stefan; Roth, Wilfried; Hausen, Anne; Gaida, Matthias M., 2023, "Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data]", https://doi.org/10.11588/data/YAZWJW, heiDATA, V1, UNF:6:gpQyF/jPYXHbW7GvjUboGQ== [fileUNF] Differentiation of neoplastic and non-neoplastic liver lesions using routine histological tissue sections can be challenging. Correct classification is paramount to forecast prognosis and to select the correct therapy. Deep learning algorithms have recently been suggested to supp...
Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis] Jul 28, 2023 - Forschungsgruppe AG Nikendei Nowak, Jonathan; Nikendei, Christoph; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Kindermann, David, 2023, "Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis]", https://doi.org/10.11588/data/AJKTKU, heiDATA, V1 This dataset contains the complete analysis and results which were conducted for the study 'Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders' within one RMarkdown-Sheet.
German funders' data sharing policies - A qualitative interview study [interview excerpts] Aug 15, 2023 - NCT - Section of Translational Medical Ethics Anger, Michael; Wendelborn, Christian; Schickhardt, Christoph, 2023, "German funders' data sharing policies - A qualitative interview study [interview excerpts]", https://doi.org/10.11588/data/FJAG0X, heiDATA, V1 Background Data sharing is commonly seen as beneficial for science, but is not yet common practice. Research funding agencies are known to play a key role in promoting data sharing, but German funders’ data sharing policies appear to lag behind in international comparison. This s...
Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST [data] Oct 18, 2023 - Computer Assisted Clinical Medicine Tönnes, Christian; Zöllner, Frank, 2023, "Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST [data]", https://doi.org/10.11588/data/GIWRQA, heiDATA, V1 Data for the Paper: "Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST" https://doi.org/10.3390/app13169179 Abstract: Background: For the reconstruction of Cone-Beam CT volumes, the exact position of each projection is needed; howe...
Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results] Sep 18, 2023 - Forschungsgruppe AG Nikendei Kindermann, David; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Nikendei, Christoph, 2023, "Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results]", https://doi.org/10.11588/data/MYFILV, heiDATA, V4 Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy). We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.
Digital Appendix: Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy Sep 29, 2023 - Functional Neuroanatomy Asan, Livia, 2023, "Digital Appendix: Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy", https://doi.org/10.11588/data/TPZWAE, heiDATA, V1, UNF:6:E5Th/vUc0jX9a3OPVhNHfQ== [fileUNF] This is the digital appendix to the dissertation by Livia Asan, titled "Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy", at the Faculty of Medicine, Heidelberg, Rup...

Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data]

Dec 4, 2023 - HITS MBM

Roessner Rita; Michelarakis, Nicholas; Gräter, Frauke; Aponte-Santamaría, Camilo, 2023, "Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites [data]", https://doi.org/10.11588/data/EZHMDU, heiDATA, V1

Plasmodium falciparum (Pf) is responsible for the most lethal form of malaria. VAR2CSA is an adhesin protein expressed by this parasite at the membrane of infected erythrocytes for attachment to the placenta, leading to pregnancy-associated malaria. VAR2CSA is a large 355 kDa mul...

Koordinierungszentrum für Klinische Studien(Medizinische Fakultät der Universität Heidelberg und Universitätsklinikum Heidelberg)

Apr 19, 2023

Open-Data-Veröffentlichungen des Koordinierungszentrums für Klinische Studien am Universitätsklinikum Heidelberg und der medizinischen Fakultät Heidelberg.

Intrinsically disordered region of talin’s FERM domain functions as an initial PIP2 recognition site [research data]

Feb 15, 2023 - HITS MBM

Buhr, Jannik; Franz, Florian; Gräter, Frauke, 2023, "Intrinsically disordered region of talin’s FERM domain functions as an initial PIP2 recognition site [research data]", https://doi.org/10.11588/data/BQTQUN, heiDATA, V1

Focal adhesions (FAs) mediate the interaction of the cytoskeleton with the extracellular matrix (ECM) in a highly dynamic fashion. talin is a central regulator, adaptor protein and mechano-sensor of focal adhesion complexes. For recruitment and firm attachment at FAs, talin’s N-t...

Integrative Virology(Center for Integrative Infectious Diseases Research (CIID), Heidelberg University Hospital)

Apr 18, 2023

The Center for Integrative Infectious Diseases Research is a state-of-the art research facility of the Department for Infectious Diseases at the University Hospital Heidelberg. Our mission is to define pathogenic principles of major human pathogens and to translate these findings...

Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data]

Jul 7, 2023 - AG Computational Diagnostic

Kriegsmann, Mark; Kriegsmann, Katharina; Steinbuss, Georg; Zgorzelski, Christiane; Albrecht, Thomas; Heinrich, Stefan; Farkas, Stefan; Roth, Wilfried; Hausen, Anne; Gaida, Matthias M., 2023, "Implementation of deep learning in liver pathology optimizes diagnosis of benign lesions and adenocarcinoma metastasis [data]", https://doi.org/10.11588/data/YAZWJW, heiDATA, V1, UNF:6:gpQyF/jPYXHbW7GvjUboGQ== [fileUNF]

Differentiation of neoplastic and non-neoplastic liver lesions using routine histological tissue sections can be challenging. Correct classification is paramount to forecast prognosis and to select the correct therapy. Deep learning algorithms have recently been suggested to supp...

Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis]

Jul 28, 2023 - Forschungsgruppe AG Nikendei

Nowak, Jonathan; Nikendei, Christoph; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Kindermann, David, 2023, "Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders [Analysis]", https://doi.org/10.11588/data/AJKTKU, heiDATA, V1

This dataset contains the complete analysis and results which were conducted for the study 'Impact of adverse and protective childhood experiences on symptom improvement rate of anxiety disorders' within one RMarkdown-Sheet.

German funders' data sharing policies - A qualitative interview study [interview excerpts]

Aug 15, 2023 - NCT - Section of Translational Medical Ethics

Anger, Michael; Wendelborn, Christian; Schickhardt, Christoph, 2023, "German funders' data sharing policies - A qualitative interview study [interview excerpts]", https://doi.org/10.11588/data/FJAG0X, heiDATA, V1

Background Data sharing is commonly seen as beneficial for science, but is not yet common practice. Research funding agencies are known to play a key role in promoting data sharing, but German funders’ data sharing policies appear to lag behind in international comparison. This s...

Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST [data]

Oct 18, 2023 - Computer Assisted Clinical Medicine

Tönnes, Christian; Zöllner, Frank, 2023, "Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST [data]", https://doi.org/10.11588/data/GIWRQA, heiDATA, V1

Data for the Paper: "Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST" https://doi.org/10.3390/app13169179 Abstract: Background: For the reconstruction of Cone-Beam CT volumes, the exact position of each projection is needed; howe...

Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results]

Sep 18, 2023 - Forschungsgruppe AG Nikendei

Kindermann, David; Rollmann, Ivo; Orth, Maximilian; Friederich, Hans-Christoph; Nikendei, Christoph, 2023, "Direct and indirect effects of adverse and protective childhood experiences on symptom improvement in psychotherapy [results]", https://doi.org/10.11588/data/MYFILV, heiDATA, V4

Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy). We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.

Digital Appendix: Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy

Sep 29, 2023 - Functional Neuroanatomy

Asan, Livia, 2023, "Digital Appendix: Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy", https://doi.org/10.11588/data/TPZWAE, heiDATA, V1, UNF:6:E5Th/vUc0jX9a3OPVhNHfQ== [fileUNF]

This is the digital appendix to the dissertation by Livia Asan, titled "Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy", at the Faculty of Medicine, Heidelberg, Rup...

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