3D Matter Made to Order (3DMM2O)

Data publications from the Cluster of Excellence 3D Matter Made to Order (3DMM2O). The Cluster is a collaboration of Karlsruhe Institute of Technology (KIT) and Heidelberg University. It pursues an interdisciplinary approach through conjunction of natural, engineering, and social sciences. 3DMM2O establishes scalable digital 3D Additive Manufacturing transcending from the molecular to the macroscopic scale. The goal is the ultimate digitalization of 3D manufacturing and material processing.

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1 to 10 of 28 Results

In Situ Fabrication of Constraints for Multicellular Micro-Spheroids Using Two-Photon Lithography [data] Mar 11, 2024 Taale, Mohammadreza, 2024, "In Situ Fabrication of Constraints for Multicellular Micro-Spheroids Using Two-Photon Lithography [data]", https://doi.org/10.11588/data/5VKT64, heiDATA, V2 2-photon polymerization is a promising technology for creating complex, microscale 3D matrices for biomedical and also bioprinting applications. Cancer research provides compelling uses for this strategy, in particular, for generating a 3D constraint around multicellular spheroid...
Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures [data] Mar 4, 2024 Catt, Samantha; Hackner, Maximillian; Spatz, Joachim P.; Blasco, Eva, 2024, "Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures [data]", https://doi.org/10.11588/data/T2SJZC, heiDATA, V1 Macromolecules with complex, defined structures exist in nature but rarely is this degree of control afforded in synthetic macromolecules. Sequence-defined approaches provide a solution for precise control of the primary macromolecular structure. Despite a growing interest, very...
An Engineered β-Hairpin Peptide Forming Thermostable Complexes with ZnII, NiII, and CuII through a His3 Site [Research Data] Feb 19, 2024 - Thomas Lab Pham, Truc Lam; Fazliev, Sunnatullo; Baur, Philipp; Comba, Peter; Thomas, Franziska, 2024, "An Engineered β-Hairpin Peptide Forming Thermostable Complexes with ZnII, NiII, and CuII through a His3 Site [Research Data]", https://doi.org/10.11588/data/SIESG0, heiDATA, V1 The three-dimensional structure of a peptide, which determines its function, can denature at elevated temperatures, in the presence of chaotropic reagents, or in organic solvents. These factors limit the applicability of peptides. Herein, we present an engineered β-hairpin peptid...
Triggered contraction of self-assembled micron-scale DNA nanotube rings [Research Data] Feb 16, 2024 - Göpfrich Group - Biophysical Engineering of Life Illig, Maja; Jahnke, Kevin; Weise, Lukas P.; Scheffold, Marlene; Mersdorf, Ulrike; Drechsler, Hauke; Zhang, Yixin; Diez, Stefan; Kierfeld, Jan; Göpfrich, Kerstin, 2024, "Triggered contraction of self-assembled micron-scale DNA nanotube rings [Research Data]", https://doi.org/10.11588/data/ADYUNN, heiDATA, V1, UNF:6:AJdXI51lTUqvs4V/XCVPZQ== [fileUNF] Contractile rings formed from cytoskeletal filaments mediate the division of cells. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes as mimics of cytoskeletal filaments and a...
A Minimalistic, Synthetic Cell-Inspired Metamaterial for Enabling Reversible Strain-Stiffening [data] Feb 16, 2024 Taale, Mohammadreza, 2024, "A Minimalistic, Synthetic Cell-Inspired Metamaterial for Enabling Reversible Strain-Stiffening [data]", https://doi.org/10.11588/data/MNMLVX, heiDATA, V1 Strain-stiffening, i.e. the nonlinear stiffening of a material in response to a strain, is an intrinsic feature of many biological systems, including skin, blood vessels, and single cells. To avoid a mismatch in mechanical properties, synthetic materials in contact with such biol...
Multimaterial 3D Laser Printing of Cell-Adhesive and Cell-Repellent Hydrogels [data] Feb 16, 2024 Schwegler, Niklas; Tanisha Gebert; Maria Villiou; Federico Colombo; Barbara Schamberger; Christine Selhuber-Unkel; Franziska Thomas; Eva Blasco, 2024, "Multimaterial 3D Laser Printing of Cell-Adhesive and Cell-Repellent Hydrogels [data]", https://doi.org/10.11588/data/V2XXS8, heiDATA, V1 This study introduces a straightforward method for manufacturing 3D microstructured cell-adhesive and cell-repellent multimaterials using two-photon laser printing. Compared to existing strategies, this approach offers bottom-up molecular control, high customizability and rapid a...
Relationship of Thermostability and Binding Affinity in Metal-binding WW-Domain Minireceptors [Research Data] Feb 9, 2024 - Thomas Lab Pham, Truc Lam; Conde González, Marcos Rafael; Fazliev, Sunnatullo; Kishore, Agi; Comba, Peter; Thomas, Franziska, 2024, "Relationship of Thermostability and Binding Affinity in Metal-binding WW-Domain Minireceptors [Research Data]", https://doi.org/10.11588/data/QSJTR0, heiDATA, V1 The design of metallo-miniproteins advances our understanding of the structural and functional roles of metals in proteins. We recently designed a metal-binding WW domain, WW-CA-Nle, which displays three histidine residues on its surface for coordination of divalent metals Ni(II)...
Rapid On-Resin N-Formylation of Peptides as One-Pot Reaction [Research Data] Feb 9, 2024 - Thomas Lab Kokollari, Agon; Werner, Marius; Lindner, Christina; Pham, Truc Lam; Thomas, Franziska, 2024, "Rapid On-Resin N-Formylation of Peptides as One-Pot Reaction [Research Data]", https://doi.org/10.11588/data/00RULE, heiDATA, V1 N-formylation is a common pre- and post-translational modification of the N-terminus or the lysine side chain of peptides and proteins that plays a role in the initiation of immune responses, gene expression, or epigenetics. Despite its high biological relevance, protocols for th...
Designing Sustainable Polymers: Lactate Esters for 3D Printing and Upcycling [data] Oct 13, 2023 - Blasco Group Klee, Pia S.; Vazquez-Martel, Clara; Florido Martins, Lilliana; Blasco, Eva, 2023, "Designing Sustainable Polymers: Lactate Esters for 3D Printing and Upcycling [data]", https://doi.org/10.11588/data/NUIXMG, heiDATA, V1 The search for sustainable polymer systems is key to tackling the current climate crisis. However, the use of bio-based polymers does not suffice to achieve this goal. Additionally, new chemical approaches enabling the re- or upcycling of polymer materials need to be explored. He...
Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data] Feb 10, 2023 - Thomas Lab Thomas, Franziska; Neitz, Hermann; Paul, Niels Benjamin; Häge, Florian; Lindner, Christina; Graebner, Roman; Kovermann, Michael, 2023, "Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data]", https://doi.org/10.11588/data/SGN2CN, heiDATA, V1 β-Sheet motifs such as the WW domain are increasingly being explored as building blocks for synthetic biological applications. Since the sequence-structure relationships of β-sheet motifs are generally complex compared to the well-studied α-helical coiled coil (CC), other approac...

In Situ Fabrication of Constraints for Multicellular Micro-Spheroids Using Two-Photon Lithography [data]

Mar 11, 2024

Taale, Mohammadreza, 2024, "In Situ Fabrication of Constraints for Multicellular Micro-Spheroids Using Two-Photon Lithography [data]", https://doi.org/10.11588/data/5VKT64, heiDATA, V2

2-photon polymerization is a promising technology for creating complex, microscale 3D matrices for biomedical and also bioprinting applications. Cancer research provides compelling uses for this strategy, in particular, for generating a 3D constraint around multicellular spheroid...

Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures [data]

Mar 4, 2024

Catt, Samantha; Hackner, Maximillian; Spatz, Joachim P.; Blasco, Eva, 2024, "Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures [data]", https://doi.org/10.11588/data/T2SJZC, heiDATA, V1

Macromolecules with complex, defined structures exist in nature but rarely is this degree of control afforded in synthetic macromolecules. Sequence-defined approaches provide a solution for precise control of the primary macromolecular structure. Despite a growing interest, very...

An Engineered β-Hairpin Peptide Forming Thermostable Complexes with ZnII, NiII, and CuII through a His3 Site [Research Data]

Feb 19, 2024 - Thomas Lab

Pham, Truc Lam; Fazliev, Sunnatullo; Baur, Philipp; Comba, Peter; Thomas, Franziska, 2024, "An Engineered β-Hairpin Peptide Forming Thermostable Complexes with ZnII, NiII, and CuII through a His3 Site [Research Data]", https://doi.org/10.11588/data/SIESG0, heiDATA, V1

The three-dimensional structure of a peptide, which determines its function, can denature at elevated temperatures, in the presence of chaotropic reagents, or in organic solvents. These factors limit the applicability of peptides. Herein, we present an engineered β-hairpin peptid...

Triggered contraction of self-assembled micron-scale DNA nanotube rings [Research Data]

Feb 16, 2024 - Göpfrich Group - Biophysical Engineering of Life

Illig, Maja; Jahnke, Kevin; Weise, Lukas P.; Scheffold, Marlene; Mersdorf, Ulrike; Drechsler, Hauke; Zhang, Yixin; Diez, Stefan; Kierfeld, Jan; Göpfrich, Kerstin, 2024, "Triggered contraction of self-assembled micron-scale DNA nanotube rings [Research Data]", https://doi.org/10.11588/data/ADYUNN, heiDATA, V1, UNF:6:AJdXI51lTUqvs4V/XCVPZQ== [fileUNF]

Contractile rings formed from cytoskeletal filaments mediate the division of cells. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes as mimics of cytoskeletal filaments and a...

A Minimalistic, Synthetic Cell-Inspired Metamaterial for Enabling Reversible Strain-Stiffening [data]

Feb 16, 2024

Taale, Mohammadreza, 2024, "A Minimalistic, Synthetic Cell-Inspired Metamaterial for Enabling Reversible Strain-Stiffening [data]", https://doi.org/10.11588/data/MNMLVX, heiDATA, V1

Strain-stiffening, i.e. the nonlinear stiffening of a material in response to a strain, is an intrinsic feature of many biological systems, including skin, blood vessels, and single cells. To avoid a mismatch in mechanical properties, synthetic materials in contact with such biol...

Multimaterial 3D Laser Printing of Cell-Adhesive and Cell-Repellent Hydrogels [data]

Feb 16, 2024

Schwegler, Niklas; Tanisha Gebert; Maria Villiou; Federico Colombo; Barbara Schamberger; Christine Selhuber-Unkel; Franziska Thomas; Eva Blasco, 2024, "Multimaterial 3D Laser Printing of Cell-Adhesive and Cell-Repellent Hydrogels [data]", https://doi.org/10.11588/data/V2XXS8, heiDATA, V1

This study introduces a straightforward method for manufacturing 3D microstructured cell-adhesive and cell-repellent multimaterials using two-photon laser printing. Compared to existing strategies, this approach offers bottom-up molecular control, high customizability and rapid a...

Relationship of Thermostability and Binding Affinity in Metal-binding WW-Domain Minireceptors [Research Data]

Feb 9, 2024 - Thomas Lab

Pham, Truc Lam; Conde González, Marcos Rafael; Fazliev, Sunnatullo; Kishore, Agi; Comba, Peter; Thomas, Franziska, 2024, "Relationship of Thermostability and Binding Affinity in Metal-binding WW-Domain Minireceptors [Research Data]", https://doi.org/10.11588/data/QSJTR0, heiDATA, V1

The design of metallo-miniproteins advances our understanding of the structural and functional roles of metals in proteins. We recently designed a metal-binding WW domain, WW-CA-Nle, which displays three histidine residues on its surface for coordination of divalent metals Ni(II)...

Rapid On-Resin N-Formylation of Peptides as One-Pot Reaction [Research Data]

Feb 9, 2024 - Thomas Lab

Kokollari, Agon; Werner, Marius; Lindner, Christina; Pham, Truc Lam; Thomas, Franziska, 2024, "Rapid On-Resin N-Formylation of Peptides as One-Pot Reaction [Research Data]", https://doi.org/10.11588/data/00RULE, heiDATA, V1

N-formylation is a common pre- and post-translational modification of the N-terminus or the lysine side chain of peptides and proteins that plays a role in the initiation of immune responses, gene expression, or epigenetics. Despite its high biological relevance, protocols for th...

Designing Sustainable Polymers: Lactate Esters for 3D Printing and Upcycling [data]

Oct 13, 2023 - Blasco Group

Klee, Pia S.; Vazquez-Martel, Clara; Florido Martins, Lilliana; Blasco, Eva, 2023, "Designing Sustainable Polymers: Lactate Esters for 3D Printing and Upcycling [data]", https://doi.org/10.11588/data/NUIXMG, heiDATA, V1

The search for sustainable polymer systems is key to tackling the current climate crisis. However, the use of bio-based polymers does not suffice to achieve this goal. Additionally, new chemical approaches enabling the re- or upcycling of polymer materials need to be explored. He...

Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data]

Feb 10, 2023 - Thomas Lab

Thomas, Franziska; Neitz, Hermann; Paul, Niels Benjamin; Häge, Florian; Lindner, Christina; Graebner, Roman; Kovermann, Michael, 2023, "Identification of novel functional mini-receptors by combinatorial screening of split-WW domains [Research Data]", https://doi.org/10.11588/data/SGN2CN, heiDATA, V1

β-Sheet motifs such as the WW domain are increasingly being explored as building blocks for synthetic biological applications. Since the sequence-structure relationships of β-sheet motifs are generally complex compared to the well-studied α-helical coiled coil (CC), other approac...

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