Persistent Identifier
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doi:10.11588/data/U1O0NB |
Publication Date
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2023-02-01 |
Title
| Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues [data] |
Author
| Miriam Abad (Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Zaragoza, Pedro Cerbuna, 12, Zaragoza 50009, Spain) - ORCID: 0000-0002-8677-3316
Martina Nardi (Institute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen 76344, Germany)
Luis Oriol (Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Zaragoza, Pedro Cerbuna, 12, Zaragoza 50009, Spain) - ORCID: 0000-0002-0922-5615
Milagros Piñol (Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Zaragoza, Pedro Cerbuna, 12, Zaragoza 50009, Spain) - ORCID: 0000-0001-5556-2172
Eva Blasco (Organic Chemistry Institute, University of Heidelberg, In Neuenheimer Feld 270, Germany; Institute for Molecular Systems Engineering and Advanced Materials, University of Heidelberg, In Neuenheimer Feld 225, Germany) - ORCID: 0000-0002-0849-4223 |
Point of Contact
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Eva Blasco (Organic Chemistry Institute, University of Heidelberg, In Neuenheimer Feld 270, Germany; Institute for Molecular Systems Engineering and Advanced Materials, University of Heidelberg, In Neuenheimer Feld 225, Germany) |
Description
| Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG124-b-PDAP9-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies. (2022-11-21) |
Subject
| Chemistry |
Related Publication
| Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues. Miriam Abad, Martina Nardi, Luis Oriol, Milagros Piñol and Eva Blasco, Polym. Chem., 2022 doi: 10.1039/D2PY01250B https://doi.org/10.1039/D2PY01250B |
Funding Information
| “Programa Excelencia” (MINECO)-FEDER by the Spanish Ministry of Economy and Competitiveness (Ministerio de Economía y Competitividad): MAT2017-84838-P
“Programa Generación de Conocimiento” (MICINN)-FEDER by the Spanish Ministry of Economy and Competitiveness (Ministerio de Economía y Competitividad): PID2021-126132NB-I00
“Fondo Social Europeo and Gobierno de Aragón” and “Fondo Europeo de Desarrollo Regional”: E47-17R, FEDER 2014-2020 “Construyendo Europa desde Aragón”
Gobierno de Aragón and Fondo Social Europeo: PhD Grant of Miriam Abad
Carl Zeiss Foundation: “Carl-Zeiss-Foundation-Focus@HEiKA”
Excellence Cluster “3D Matter Made to Order”: EXC-2082/1-390761711
Helmholtz program “Materials Systems Engineering” |