Persistent Identifier
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doi:10.11588/data/AMDH7G |
Publication Date
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2024-01-26 |
Title
| Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain [data] |
Author
| Marty-Lombardi, Sebastián (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany) - ORCID: 0000-0001-8309-9875
Lu, Shiying (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany; Present address: Oliver Wyman GmbH, Muellerstrasse 3, 80469, Munich, Germany)
Ambroziak, Wojciech (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany; Present address: Department of Translational Disease Understanding, Grünenthal GmbH, Zieglerstraße 6, 52078 Aachen, Germany) - ORCID: 0000-0002-3801-5908
Schrenk-Siemens, Katrin (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany)
Wang, Jialin (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany)
DePaoli-Roach, Anna A. (Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA) - ORCID: 0000-0002-4252-4369
Hagenston, Anna M. (Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany) - ORCID: 0000-0001-7747-5336
Wende, Hagen (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany; Present address: Taconic Biosciences, Marie-Curie-Strasse 10, 51377 Leverkusen, Germany) - ORCID: 0000-0002-9168-8095
Tappe-Theodor, Anke (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany) - ORCID: 0000-0002-9343-7580
Simonetti, Manuela (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany) - ORCID: 0000-0003-0056-7595
Bading, Hilmar (Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany)
Okun, Jürgen G. (Dietmar-Hopp-Metabolic Center, Division of Neuropaediatrics and Metabolic Medicine, Im Neuenheimer Feld 669, Heidelberg University, 69120 Heidelberg, Germany)
Kuner, Rohini (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany) - ORCID: 0000-0002-3333-9129
Fleming, Thomas (Department of Endocrinology, Diabetology, Metabolism and Clinical Chemistry (Internal Medicine 1), Heidelberg University Hospital, 69120 Heidelberg, Germany; German Center of Diabetes Research (DZD), Neuherberg, Germany)
Siemens, Jan (Institute of Pharmacology, Im Neuenheimer Feld 366, Heidelberg University, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany) - ORCID: 0000-0001-9051-9217 |
Point of Contact
|
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Siemens, Jan (Heidelberg University, Department of Pharmacology) |
Description
| Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic coupling between astrocytes and neurons has been implicated in neuronal plasticity and memory formation in the CNS, but neither its involvement in pathological pain nor in spinal plasticity has been tested. Here, we report a form of neuroglia signaling involving spinal astrocytic glycogen dynamics triggered by persistent noxious stimulation via upregulation of the Protein Targeting to Glycogen (PTG) in spinal astrocytes. PTG drove glycogen build-up in astrocytes, and blunting glycogen accumulation and turnover by Ptg gene deletion reduced pain-related behaviors and promoted faster recovery by shortening pain maintenance in mice. Furthermore, mechanistic analyses revealed that glycogen dynamics is a critically required process for maintenance of pain by facilitating neuronal plasticity in spinal lamina 1 neurons. In summary, our study describes a previously unappreciated mechanism of astrocyte-neuron metabolic communication through glycogen breakdown in the spinal cord that fuels spinal neuron hyperexcitability. (2024-01-23) |
Subject
| Medicine, Health and Life Sciences |
Keyword
| pain
energy metabolism
glycogen
spinal cord |
Topic Classification
| energy metabolism in pain hypersensitivity |
Related Publication
| Marty-Lombardi, S., Lu, S., Ambroziak, W. et al. Neuron–astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain. Nat Metab (2024). doi: 10.1038/s42255-024-01001-2 https://doi.org/10.1038/s42255-024-01001-2 |
Language
| English |
Producer
| Siemens, Jan (Heidelberg University) https://siemenslab.de/ |
Production Location
| Heidelberg University |
Funding Information
| Deutsche Forschungsgemeinschaft (DFG)DFG: SFB1158
European Research Council: ERC-CoG-772395
International Human Frontier Science Program Organization: LT000762/2019-L |
Distributor
| Gimenez-Cassina, Alfredo (Nature Metabolism) https://www.nature.com/natmetab/ |
Depositor
| Siemens, Jan |
Deposit Date
| 2024-01-22 |
Data Type
| Experimental data (histology, PCR, metabolite analysis, behavior analysis etc) |