Persistent Identifier
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doi:10.11588/data/2NZSXC |
Publication Date
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2024-04-18 |
Title
| Programme costs of longer and shorter tuberculosis drug regimens and drug import: a modelling study for Karakalpakstan, Uzbekistan [Research Data] |
Author
| Kohler, Stefan (Heidelberg University, Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health, Heidelberg, Germany and Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Social Medicine, Epidemiology and Health Economics, Berlin, Germany) - ORCID: 0000-0003-1365-7506
Sitali, Norman (Médecins Sans Frontières, Berlin, Germany) - ORCID: 0000-0003-2186-8530
Achar, Jay (Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden) - ORCID: 0000-0002-2521-4422
Paul, Nicolas (Heidelberg University, Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health, Heidelberg, Germany) - ORCID: 0000-0003-2228-3980 |
Point of Contact
|
Use email button above to contact.
Kohler, Stefan (Heidelberg University, Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health, Heidelberg, Germany and Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Social Medicine, Epidemiology and Health Economics, Berlin, Germany) |
Description
| Background: The introduction of new and often shorter tuberculosis (TB) drug regimens affects the cost of TB programmes. Methods: We modelled drug purchase and import costs for 20-month, 9-month and 4- to 6-month TB drug regimens based on 2016–2020 treatment numbers from a TB programme in Karakalpakstan, Uzbekistan, and 2021 Global Drug Facility prices. Results: On average, 2225±374 (±sd) people per year started TB treatment, 30±2.1% of whom were diagnosed with drug-resistant forms of TB. Transitioning from a 6-month to a 4-month drug-susceptible (DS)-TB drug regimen increased the TB programme's annual DS-TB drug cost from USD 65±10 K to USD 357±56 K (p<0.001) and its drug import cost from USD 6.4±1.0 K to USD 9.3±1.4 K (p=0.008). Transitioning from a 20-month all-oral multidrug-resistant (MDR)-TB drug regimen to a 9-month MDR-TB drug regimen with an injectable antibiotic decreased the TB programme's annual MDR-TB drug cost from USD 1336±265 K to USD 266±53 K (p<0.001) and had no significant effect on the drug import cost (USD 28±5.5 K versus USD 27±5.4 K; p=0.88). Purchasing (USD 577±114 K) and importing (USD 3.0±0.59 K) the 6-month all-oral MDR-TB drug regimen cost more than procuring the 9-month MDR-TB drug regimen but less than the 20-month all-oral MDR-TB drug regimen (both p<0.01). Conclusion: Introducing new and shorter TB drug regimens could increase the cost of TB programmes with low drug resistance rates and decrease the cost of TB programmes with high drug resistance rates. |
Subject
| Medicine, Health and Life Sciences |
Keyword
| drug innovation
drug procurement
program expenses
shipping costs
tuberculosis control
former Soviet Union countries |
Related Publication
| Kohler S, Sitali N, Achar J, Paul N. Programme costs of longer and shorter tuberculosis drug regimens and drug import: a modelling study for Karakalpakstan, Uzbekistan. ERJ Open Research 2022; 8: 00622-2021. doi: 10.1183/23120541.00622-2021 https://doi.org/10.1183/23120541.00622-2021 |
Language
| English |
Time Period
| Start Date: 2016 ; End Date: 2020 |