|
View: |
Part 1: Document Description
|
|
Citation |
|
|---|---|
|
Title: |
Performance of Covid-19 antigen rapid diagnostic tests for self-testing compared with antigen testing by professionals and molecular tests: A systematic review and meta-analysis [Research Data] |
|
Identification Number: |
doi:10.11588/data/P9JEPG |
|
Distributor: |
heiDATA |
|
Date of Distribution: |
2022-12-02 |
|
Version: |
4 |
|
Bibliographic Citation: |
Katzenschlager, Stephan; Brümmer, Lukas E.; Schmitz, Stephani; Tolle, Hannah; Manten, Katharina; Gaeddert, Mary; Erdmann, Christian; Lindner, Andreas; Tobian, Frank; Grilli, Maurizio; Pollock, Nira R.; Mace, Aurélien; Erkosar, Berra; Carmona, Sergio; Ongarello, Stefano; Johnson, Cheryl C.; Sacks, Jilian A.; Denkinger, Claudia M.; Yerlikaya, Seda, 2022, "Performance of Covid-19 antigen rapid diagnostic tests for self-testing compared with antigen testing by professionals and molecular tests: A systematic review and meta-analysis [Research Data]", https://doi.org/10.11588/data/P9JEPG, heiDATA, V4, UNF:6:RY3iu11KOsyU6jlqoBsj2A== [fileUNF] |
|
Citation |
|
|
Title: |
Performance of Covid-19 antigen rapid diagnostic tests for self-testing compared with antigen testing by professionals and molecular tests: A systematic review and meta-analysis [Research Data] |
|
Identification Number: |
doi:10.11588/data/P9JEPG |
|
Authoring Entity: |
Katzenschlager, Stephan (Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany) |
|
Brümmer, Lukas E. (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) |
|
|
Schmitz, Stephani (Department of Developmental Biology, Erasmus Medical Center, Rotterdam, Netherlands) |
|
|
Tolle, Hannah (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) |
|
|
Manten, Katharina (Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany) |
|
|
Gaeddert, Mary (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) |
|
|
Erdmann, Christian (FH Muenster University of Applied Sciences, Muenster, Germany) |
|
|
Lindner, Andreas (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Hum-boldt- Universität zu Berlin, and Berlin Institute of Health; Institute of Tropical Medicine and International Health, Berlin, Germany) |
|
|
Tobian, Frank (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) |
|
|
Grilli, Maurizio (Library, University Medical Center Mannheim, Mannheim, Germany) |
|
|
Pollock, Nira R. (Department of Laboratory Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America) |
|
|
Mace, Aurélien (FIND, Geneva, Switzerland) |
|
|
Erkosar, Berra (FIND, Geneva, Switzerland) |
|
|
Carmona, Sergio (FIND, Geneva, Switzerland) |
|
|
Ongarello, Stefano (FIND, Geneva, Switzerland) |
|
|
Johnson, Cheryl C. (Global HIV, Hepatitis and STIs Programmes, World Health Organization, Geneva, Switzer-land) |
|
|
Sacks, Jilian A. (Department of Epidemic and Pandemic Preparedness and Prevention, World Health Organi-zation, Geneva, Switzerland) |
|
|
Denkinger, Claudia M. (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) |
|
|
Yerlikaya, Seda (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) |
|
|
Distributor: |
heiDATA |
|
Access Authority: |
Katzenschlager, Stephan |
|
Holdings Information: |
https://doi.org/10.11588/data/P9JEPG |
|
Study Scope |
|
|
Keywords: |
Medicine, Health and Life Sciences, SARS-CoV-2, Ag-RDT, antigen testing, systematic review, self testing |
|
Abstract: |
Objectives Self-testing is an effective tool to bridge the testing gap for a number of infectious diseas-es; however, its performance using SARS-CoV-2 antigen-detection rapid diagnostic tests (Ag-RDTs) has not been systematically reviewed. We evaluated the accuracy of COVID-19 self-testing and/or self-sampling using Ag-RDTs to inform WHO guideline development. Methods: We searched multiple databases for articles evaluating the accuracy of COVID-19 self-testing or self-sampling through November 19th, 2021. Cohen’s kappa was estimated to as-sess concordance between self-testing/self-sampling and solely professional-use Ag-RDT results. Meta-analysis was performed to obtain pooled performance estimates compared to molecular testing. The QUADAS-2 and GRADE tools were used to evaluate quality and cer-tainty of evidence. Results: Of 12,946 publications, 19 were eligible; two reported on self-testing, while 17 studies as-sessed self-sampling only. Risk of bias was low (28.1%). Overall concordance with profes-sional-use Ag-RDTs (n=5) was high (kappa 0.92 [95% confidence interval (CI) 0.89 to 0.95]). Overall pooled sensitivity of Ag-RDT testing using self-testing/self-sampling was 72.0% (95% CI 62.4 to 80.0). Conclusion: COVID-19 self-testing/self-sampling exhibits reasonable performance and high concordance with professional-use Ag-RDTs. This suggest that self-sampling, at a minimum, can be offered as part of COVID-19 testing strategies, despite high heterogeneity among studies and the paucity of data. |
|
Methodology and Processing |
|
|
Sources Statement |
|
|
Data Access |
|
|
Other Study Description Materials |
|
|
File Description--f16132 |
|
|
File: Self-collection Antigen Test Systematic Review 2023-11-10.tab |
|
|
|
|
Notes: |
UNF:6:RY3iu11KOsyU6jlqoBsj2A== |
|
List of Variables: | |
|
Variables |
|
|
f16132 Location: |
Variable Format: character Notes: UNF:6:ot778y06knzv7PZf1OUpjw== |
|
f16132 Location: |
Variable Format: character Notes: UNF:6:gMIJWGusjnqM1D2uiXxwGg== |
|
f16132 Location: |
Summary Statistics: Valid 45.0; Min. 2020.0; Mean 2020.0; Max. 2020.0; StDev 0.0 Variable Format: numeric Notes: UNF:6:uiD81flN9R7NnIxTZ16X4w== |
|
f16132 Location: |
Variable Format: character Notes: UNF:6:8acpCs6yAYNjYd6WfWTYSw== |
|
f16132 Location: |
Variable Format: character Notes: UNF:6:Q5HAd/jTK1SuVBvIFuLkAg== |
|
f16132 Location: |
Variable Format: character Notes: UNF:6:pAifqQoGXBy1oQ37UrflXA== |
|
f16132 Location: |
Summary Statistics: Valid 0.0; Min. NaN; Mean NaN; Max. NaN; StDev NaN Variable Format: numeric Notes: UNF:6:BnPX7YFa/T9jQSEb4E01KA== |
|
Label: |
Self-collection Antigen Test Systematic Review 2023-08-10.xlsx |
|
Notes: |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |