Perfusion quantification data for "Towards Quantitative Perfusion MRI of the Lung in COPD: The Problem of Short-Term Repeatability" (doi:10.11588/data/ZPEZPX)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Perfusion quantification data for "Towards Quantitative Perfusion MRI of the Lung in COPD: The Problem of Short-Term Repeatability"

doi:10.11588/data/ZPEZPX

heiDATA

2018-11-27

1

Triphan, Simon, 2018, "Perfusion quantification data for "Towards Quantitative Perfusion MRI of the Lung in COPD: The Problem of Short-Term Repeatability"", https://doi.org/10.11588/data/ZPEZPX, heiDATA, V1, UNF:6:SE0iKbhWdsMOrcUkd706AA== [fileUNF]

Perfusion quantification data for "Towards Quantitative Perfusion MRI of the Lung in COPD: The Problem of Short-Term Repeatability"

doi:10.11588/data/ZPEZPX

Triphan, Simon (Diagnostic and Interventional Radiology, University Hospital Heidelberg, Medical Faculty Heidelberg, Heidelberg University)

PulmoMR

heiDATA

Triphan, Simon

2018-10-05

https://doi.org/10.11588/data/ZPEZPX

Medicine, Health and Life Sciences

<b>ABSTRACT</b><br /> <br /> Purpose<br /> 4D perfusion magnetic resonance imaging (MRI) with intravenous injection of contrast agent allows for a radiation-free assessment of regional lung function. It is therefore a valuable method to monitor response to treatment in patients with chronic obstructive pulmonary disease (COPD). This study was designed to evaluate its potential for monitoring short-term response to hyperoxia in COPD patients.<br /> <br /> Materials and Methods<br /> 19 prospectively enrolled COPD patients (median age 66y) underwent paired dynamic contrast-enhanced 4D perfusion MRI within 35min, first breathing 100% oxygen (injection 1, O2) and then room air (injection 2, RA), which was repeated on two consecutive days (day 1 and 2). Post-processing software was employed to calculate mean transit time (MTT), pulmonary blood volume (PBV) and pulmonary blood flow (PBF), based on the indicator dilution theory, for the automatically segmented whole lung and 12 regions of equal volume.<br /> <br /> Results<br /> Comparing O2 with RA conditions, PBF and PBV were found to be significantly lower at O2, consistently on both days (p<10-8). Comparing day 2 to day 1, MTT was shorter by 0.59±0.63 s (p<10-8), PBF was higher by 22±80 ml/min/100ml (p<3·10-4), and PBV tended to be lower by 0.2±7.2 ml/100ml (p=0.159) at both, RA and O2, conditions.<br /> <br /> Conclusion<br /> The second injection (RA) yielded higher PBF and PBV, which apparently contradicts the established hypothesis that hyperoxia increases lung perfusion. Quantification of 4D perfusion MRI by current software approaches may thus be limited by residual circulating contrast agent in the short-term and even the next day.<br /> <br /> Dataset<br /> The dataset contains the values of derived perfusion parameters, including numbers calculated using vascular suppression, as referred to in the supplement of the publication.

Functional medical data calculated from MRI measurements

• Number of cases: 1976

• No. of variables per record: 46

• Type of File: text/tab-separated-values

UNF:6:SE0iKbhWdsMOrcUkd706AA==

• PatID - PatID
• Day - Day
• RA or O2 - RA or O2
• Volume/PBF/PBV/MTT - Volume/PBF/PBV/MTT
• Lung VS - Lung VS
• Right Lung VS - Right Lung VS
• Right Upper VS - Right Upper VS
• Right Middle VS - Right Middle VS
• Right Lower VS - Right Lower VS
• Right Upper Front VS - Right Upper Front VS
• Right Upper Back VS - Right Upper Back VS
• Right Middle Front VS - Right Middle Front VS
• Right Middle Back VS - Right Middle Back VS
• Right Lower Front VS - Right Lower Front VS
• Right Lower Back VS - Right Lower Back VS
• Left Lung VS - Left Lung VS
• Left Upper VS - Left Upper VS
• Left Middle VS - Left Middle VS
• Left Lower VS - Left Lower VS
• Left Upper Front VS - Left Upper Front VS
• Left Upper Back VS - Left Upper Back VS
• Left Middle Front VS - Left Middle Front VS
• Left Middle Back VS - Left Middle Back VS
• Left Lower Front VS - Left Lower Front VS
• Left Lower Back VS - Left Lower Back VS
• Lung - Lung
• Right Lung - Right Lung
• Right Upper - Right Upper
• Right Middle - Right Middle
• Right Lower - Right Lower
• Right Upper Front - Right Upper Front
• Right Upper Back - Right Upper Back
• Right Middle Front - Right Middle Front
• Right Middle Back - Right Middle Back
• Right Lower Front - Right Lower Front
• Right Lower Back - Right Lower Back
• Left Lung - Left Lung
• Left Upper - Left Upper
• Left Middle - Left Middle
• Left Lower - Left Lower
• Left Upper Front - Left Upper Front
• Left Upper Back - Left Upper Back
• Left Middle Front - Left Middle Front
• Left Middle Back - Left Middle Back
• Left Lower Front - Left Lower Front
• Left Lower Back - Left Lower Back

f2079 Location:

Summary Statistics: Max. 20.0; StDev 5.7162764211140855; Min. 1.0; Mean 10.842105263158054; Valid 1976.0

Variable Format: numeric

Notes: UNF:6:3Y4fl60P/a3gstxG+DWwjg==

f2079 Location:

Summary Statistics: Max. 2.0; Min. 1.0; Mean 1.5; StDev 0.500126566259463; Valid 1976.0

Variable Format: numeric

Notes: UNF:6:r4ZVhvM4PHRbMM2IY4zorA==

f2079 Location:

Variable Format: character

Notes: UNF:6:pYNMEYu7GNG2DDPldZKwwA==

f2079 Location:

Variable Format: character

Notes: UNF:6:FEgUrn67LKMd+UutK8Ozrw==

f2079 Location:

Summary Statistics: Max. 7909355.16; StDev 1020355.8001451414; Min. 0.0; Mean 234551.4067459515; Valid 1976.0

Variable Format: numeric

Notes: UNF:6:HU9Q2Lb2yN5pMC2qyx0rfQ==

f2079 Location:

Summary Statistics: StDev 526739.0691015997; Mean 121679.44750506076; Min. 0.0; Valid 1976.0; Max. 3899593.35;

Variable Format: numeric

Notes: UNF:6:ABNMJyhWJmI33mVTEkEYxA==

f2079 Location:

Summary Statistics: Mean 38838.35702935221; StDev 168394.87916487549; Valid 1976.0; Min. 0.0; Max. 1310367.58

Variable Format: numeric

Notes: UNF:6:Vmp9/YpxF8uhBRyYDioDZw==

f2079 Location:

Summary Statistics: Valid 1976.0; StDev 174194.1769438636; Mean 40332.78347165994; Min. 0.0; Max. 1273097.99;

Variable Format: numeric

Notes: UNF:6:ABc+A7+oJU3pRN514k49XA==

f2079 Location:

Summary Statistics: Mean 42900.82028340081; Min. 0.0; Valid 1976.0; Max. 1349010.47; StDev 185021.62373097465;

Variable Format: numeric

Notes: UNF:6:9tBDG9zIWh2Nvp2+xW45hA==

f2079 Location:

Summary Statistics: Min. 0.0; Mean 20942.620359311735; Valid 1976.0; StDev 90644.33688137024; Max. 686912.54;

Variable Format: numeric

Notes: UNF:6:ANO7G5hX0s/ddhUUatZ6yQ==

f2079 Location:

Summary Statistics: Mean 18050.45294028341; Max. 641002.66; Valid 1976.0; Min. 0.0; StDev 78088.48237381008

Variable Format: numeric

Notes: UNF:6:RQvXioSa7wPPpoz3ZdXg8Q==

f2079 Location:

Summary Statistics: Min. 0.0; Max. 675086.98; Mean 21846.96253036438; StDev 93757.0595848149; Valid 1976.0

Variable Format: numeric

Notes: UNF:6:PqalRhGMNl3lnFYWXso/Dw==

f2079 Location:

Summary Statistics: Valid 1976.0; Mean 18656.448243927116; Max. 619812.01; StDev 80680.57878407481; Min. 0.0

Variable Format: numeric

Notes: UNF:6:+cnAb03WsVHqOcoUFQ64QQ==

f2079 Location:

Summary Statistics: Max. 737705.23; StDev 101789.67305413463; Min. 0.0; Valid 1976.0; Mean 23773.51957489879

Variable Format: numeric

Notes: UNF:6:IMGHn8MgmNa3lDpQgqxxHg==

f2079 Location:

Summary Statistics: StDev 83798.10318849233; Min. 0.0; Mean 19300.434185222664; Valid 1976.0; Max. 626621.25;

Variable Format: numeric

Notes: UNF:6:fgABbm6aT1sJ3zyIrc06qQ==

f2079 Location:

Summary Statistics: Min. 0.0; Mean 113096.11676113364; StDev 496148.58445569157; Valid 1976.0; Max. 4429492.95;

Variable Format: numeric

Notes: UNF:6:tBOb8w7J3qZpUHJFZg+SGQ==

f2079 Location:

Summary Statistics: Min. 0.0; Valid 1976.0; StDev 159280.61405323757; Max. 1424903.87; Mean 36363.78020242915

Variable Format: numeric

Notes: UNF:6:j89/YP4IO60PuczJVr5e2g==

f2079 Location:

Summary Statistics: Valid 1976.0; Mean 37315.17769736843; Min. 0.0; Max. 1498661.04; StDev 163493.26391928425

Variable Format: numeric

Notes: UNF:6:6fTONK4ZrWpcIbYwBZ2saQ==

f2079 Location:

Summary Statistics: Mean 39802.94729251013; Valid 1976.0; StDev 174100.7210094737; Max. 1505928.04; Min. 0.0

Variable Format: numeric

Notes: UNF:6:SeTYFqgsH+CzclX+Eo+TAA==

f2079 Location:

Summary Statistics: Mean 19349.27975202429; Valid 1976.0; Min. 0.0; StDev 84635.9321798852; Max. 762901.31

Variable Format: numeric

Notes: UNF:6:/9MhXFio/B7EHe5gSKrDzw==

f2079 Location:

Summary Statistics: StDev 74864.56072948594; Mean 17181.730511133606; Valid 1976.0; Min. 0.0; Max. 662002.56;

Variable Format: numeric

Notes: UNF:6:s6M93FwoNTJk0KCB88BkSg==

f2079 Location:

Summary Statistics: Mean 20470.547818825915; Valid 1976.0; Max. 772800.45; Min. 0.0; StDev 89093.26331176082

Variable Format: numeric

Notes: UNF:6:G/hT2vFfh43Y6IstBrDyWw==

f2079 Location:

Summary Statistics: Min. 0.0; Mean 17021.79662955466; Max. 725860.6; StDev 74568.54941043758; Valid 1976.0;

Variable Format: numeric

Notes: UNF:6:4Dh4/1K6VNcVnQQxT1QuFg==

f2079 Location:

Summary Statistics: Max. 795269.01; Valid 1976.0; Min. 0.0; Mean 21806.60817307692; StDev 94530.51056703745;

Variable Format: numeric

Notes: UNF:6:pOuekbFAWSRwRUua7iJFzg==

f2079 Location:

Summary Statistics: Valid 1976.0; Max. 711498.26; StDev 79924.51508426838; Min. 0.0; Mean 18168.422763157883;

Variable Format: numeric

Notes: UNF:6:Za+0T2LvCpXrpTajBCfw2A==

f2079 Location:

Summary Statistics: Min. 0.0; Max. 8741950.99; Valid 1976.0; StDev 1227908.980243414; Mean 287114.1239473684

Variable Format: numeric

Notes: UNF:6:PJcI407Mkj7hwM1MV9LhMw==

f2079 Location:

Summary Statistics: Valid 1976.0; StDev 630335.2942257272; Max. 4689331.05; Min. 0.0; Mean 147795.85139676114

Variable Format: numeric

Notes: UNF:6:/dh4O4ENCFfGTlDpKoHu5g==

f2079 Location:

Summary Statistics: Valid 1976.0; Min. 0.0; StDev 203935.47884080795; Mean 47921.59645748988; Max. 1541500.09;

Variable Format: numeric

Notes: UNF:6:x3OmeXq6vW5OZtluPjwRVg==

f2079 Location:

Summary Statistics: Min. 0.0; Mean 50155.50566801621; Valid 1976.0; Max. 1568489.07; StDev 212931.8633994376

Variable Format: numeric

Notes: UNF:6:XhcINLt5ukgz5kWHR6rqzA==

f2079 Location:

Summary Statistics: Mean 50185.04937246964; Min. 0.0; StDev 213403.21060919462; Valid 1976.0; Max. 1579341.89;

Variable Format: numeric

Notes: UNF:6:BcZnjPqku7Rmvz6gvDR/Ug==

f2079 Location:

Summary Statistics: Mean 25082.830136639674; StDev 106355.27913327487; Min. 0.0; Max. 824069.98; Valid 1976.0;

Variable Format: numeric

Notes: UNF:6:w9IX0AZr1WbblTHdIwU9PA==

f2079 Location:

Summary Statistics: Mean 23021.768917004047; Max. 717430.11; StDev 97642.85084152348; Valid 1976.0; Min. 0.0

Variable Format: numeric

Notes: UNF:6:1F0E1LV/rfrk6ZHHhuXWBA==

f2079 Location:

Summary Statistics: StDev 109460.85405312767; Mean 25862.867788461546; Valid 1976.0; Max. 795974.73; Min. 0.0

Variable Format: numeric

Notes: UNF:6:mrbL3vIL74XiBM2MBVmqWw==

f2079 Location:

Summary Statistics: StDev 103452.6625500814; Mean 24501.42050607287; Max. 772514.34; Valid 1976.0; Min. 0.0

Variable Format: numeric

Notes: UNF:6:g17q0MQ2pInkcXJwUIqOTA==

f2079 Location:

Summary Statistics: StDev 110711.02397955151; Mean 26086.291771255055; Max. 821132.66; Valid 1976.0; Min. 0.0;

Variable Format: numeric

Notes: UNF:6:U2fl9uYyCCutb13m0FqPrw==

f2079 Location:

Summary Statistics: StDev 102703.59129902106; Valid 1976.0; Max. 767974.85; Mean 24285.5862854251; Min. 0.0

Variable Format: numeric

Notes: UNF:6:n/YhlE8ldfncHxt5DgEjrQ==

f2079 Location:

Summary Statistics: Min. 0.0; StDev 600330.4922352784; Mean 139587.5210121457; Max. 4617977.14; Valid 1976.0;

Variable Format: numeric

Notes: UNF:6:SiPPpYePJHjOgta/uqqLkQ==

f2079 Location:

Summary Statistics: Min. 0.0; StDev 194529.31196103102; Valid 1976.0; Mean 45396.17518218624; Max. 1493453.98;

Variable Format: numeric

Notes: UNF:6:invtTNnZ18vn6U3IOVTfRg==

f2079 Location:

Summary Statistics: Valid 1976.0; Min. 0.0; Mean 47368.42188765181; StDev 202874.5004557099; Max. 1547756.2;

Variable Format: numeric

Notes: UNF:6:41mMG8auEeFILaNVqCMqYQ==

f2079 Location:

Summary Statistics: Mean 47275.5995242915; Valid 1976.0; Max. 1576766.97; Min. 0.0; StDev 202858.0700396551;

Variable Format: numeric

Notes: UNF:6:2+1DR7ne1Ya/Q4ESnGEg/A==

f2079 Location:

Summary Statistics: Max. 767936.71; Mean 23656.35217611336; Valid 1976.0; StDev 101023.81667011637; Min. 0.0

Variable Format: numeric

Notes: UNF:6:WAfC+L9f2m+zcFYGZb4H/g==

f2079 Location:

Summary Statistics: Min. 0.0; Max. 731163.02; Valid 1976.0; StDev 93521.67691668293; Mean 21939.665501012143

Variable Format: numeric

Notes: UNF:6:i9ANjb26uuMA7UXNPIVnOQ==

f2079 Location:

Summary Statistics: StDev 104533.45909353055; Mean 24472.187338056683; Valid 1976.0; Max. 809764.86; Min. 0.0

Variable Format: numeric

Notes: UNF:6:KLxcpktLW2ROBc/uImUHIw==

f2079 Location:

Summary Statistics: Min. 0.0; Mean 23120.18640182186; Valid 1976.0; StDev 98322.32380716955; Max. 750808.72;

Variable Format: numeric

Notes: UNF:6:PN+HyAqjkFDb6rwhUsv+tA==

f2079 Location:

Summary Statistics: Valid 1976.0; Max. 807571.41; StDev 105134.46750953364; Min. 0.0; Mean 24558.363046558705;

Variable Format: numeric

Notes: UNF:6:d/LVogKfxSvbwtfwywTL3w==

f2079 Location:

Summary Statistics: StDev 97745.16506176114; Valid 1976.0; Mean 22899.231538461543; Min. 0.0; Max. 773944.85;

Variable Format: numeric

Notes: UNF:6:fv6E6QwV5SNT/7LIIn9lpw==

Label:

data_dictionary.txt

Text:

Legend for the perfusion_data table.

text/plain