Histopathology of thymectomy specimens from the MGTX-trialdoi:10.11588/data/NWE2JJheiDATA2018-05-181Cleo-Aron Weis, 2018, "Histopathology of thymectomy specimens from the MGTX-trial", https://doi.org/10.11588/data/NWE2JJ, heiDATA, V1, UNF:6:Od2UlnHG3ctanb4ikzIx4g== [fileUNF]Histopathology of thymectomy specimens from the MGTX-trialDatabase from the analysis of morphological of thymectomy specimens obtained in the MGTX-trialdoi:10.11588/data/NWE2JJCleo-Aron WeisCleo-Aron WeisMicrosoft ExcelheiDATAInstitute of Pathology, University Medical Centre Mannheim2018-04-12Spreadsheet with data on the macroscopy and microscopy of thymectomie specimens (e.g. estimated fat content, counted number of follicles per slide). Furthermore it contains basic clinical information (e.g. age, gender, MG-duration).
Dealing with spatial data (due to a spatial work-up regime) the database is divided into a sheet for patient data (dataPatient), a sheet for summative data of all regions (dataAllRegions) and a sheet for data of the central region A (dataARegion).Medicine, Health and Life SciencesMGTX<b>Background:</b><br />
The thymectomy specimens from the “thymectomy trial in non-thymomatous myasthenia gravis patients receiving prednisone therapy” (MGTX) [1] underwent rigid and comprehensive work-up, which results in a unique, spatially mapped dataset.
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<p><img src="https://heidata.uni-heidelberg.de/api/access/datafile/1586?imageThumb=400&pfdrid_c=true"></p>
<b> Fig. 1 Specimen work-up:</b><br />
Work-up scheme for the specimens in the MGTX trial [1, 2]. Thymuses were sub-divided into regions that underwent predefined evaluation (e.g. complete work-up of the central A-region, partial work-up of other regions)
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<b>Content:</b><br />
A xlsx-file with one table for patient data (“dataPatients” with age, gender etc.), one table with histomorphological data for the specimen regions (“dataAllRegions” with grading atrophy, grading overall fat etc.) and one table for the follicle morphology in the A region (“dataARegion” with n follicle with germinal centre etc.).
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<b> References:</b><br />
1. Wolfe, G.I., et al., Randomized Trial of Thymectomy in Myasthenia Gravis. N Engl J Med, 2016. 375(6): p. 511-22. < />
2. Ströbel, P., et al., The ageing and myasthenic thymus: A morphometric study validating a standard procedure in the histological workup of thymic specimens. Journal of Neuroimmunology, 2008. 201–202: p. 64-73.
Excel spreadsheetWeis CA, Aban IB, Cutter G, Kaminski HJ, Scharff C, et al. (2018) Histopathology of thymectomy specimens from the MGTX-trial: Entropy analysis as strategy to quantify spatial heterogeneity of lymphoid follicle and fat distribution. PLOS ONE 13(6): e0197435.10.1371/journal.pone.0197435Weis CA, Aban IB, Cutter G, Kaminski HJ, Scharff C, et al. (2018) Histopathology of thymectomy specimens from the MGTX-trial: Entropy analysis as strategy to quantify spatial heterogeneity of lymphoid follicle and fat distribution. PLOS ONE 13(6): e0197435.dataBase.tab5510text/tab-separated-valuesUNF:6:Od2UlnHG3ctanb4ikzIx4g==randIDUNF:6:5nviOTwldVcyLN1qH98Qgw==age[y].63.018.012.5389091401222930.055.032.033.872727272727275UNF:6:RBn77Q5pYDNw5i5E0vgKLQ==genderUNF:6:O4L5cqcAwGfKpObOqx448w==weightpatient[kg].54.074.9185185185185270.5127.01.048.017.572910907524726UNF:6:bQmVHhQSuqOjolJ1Pe+m0g==BMI.18.52418075136755624.2804801468811321.044.536940686784626.6794194109299536.32995710177772554.0UNF:6:SKwLNABE+fu17qGeWgA/1Q==AUCprednisonebeforesurgery[g]11.08.59090909090909244.04.69.02.072416244606544411.4.UNF:6:TtCN9oXf6JT5wCuKAMStVA==AUCprednisoneaftersurgery[g].3.0139.749.1768834792327070.017.202555.019.327545454545454UNF:6:vTbFhnvkUgEWrY9oine51A==QMG-droppersistedUNF:6:5vN76snZXyDy6wYeLH/OGA==MMSpersistedUNF:6:U7ZHI+OPuOjOcGaRK/rtag==QMG-scoreatbaseline11.6481481481481491.011.5.21.054.01.05.154801415963118UNF:6:tSH5vbpN3oXepwW3Yj5JgA==abstract.jpgimage/jpeg