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Part 1: Document Description
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Citation |
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Title: |
Activity of AcD and nonAcD cells during high-frequency network oscillations [data] |
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Identification Number: |
doi:10.11588/data/JWLFFZ |
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Distributor: |
heiDATA |
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Date of Distribution: |
2022-09-22 |
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Version: |
1 |
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Bibliographic Citation: |
Hodapp, Alexander; Kaiser, Martin E.; Thome, Christian; Ding, Lingjun; Rozov, Andrei; Klumpp, Matthias; Stevens, Nikolas; Stingl, Moritz; Sackmann, Tina; Lehmann, Nadja; Draguhn, Andreas; Burgalossi, Andrea; Engelhardt, Maren; Both, Martin, 2022, "Activity of AcD and nonAcD cells during high-frequency network oscillations [data]", https://doi.org/10.11588/data/JWLFFZ, heiDATA, V1, UNF:6:IbIOEy1OPRgP05Qd2QIN4w== [fileUNF] |
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Citation |
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Title: |
Activity of AcD and nonAcD cells during high-frequency network oscillations [data] |
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Identification Number: |
doi:10.11588/data/JWLFFZ |
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Authoring Entity: |
Hodapp, Alexander (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Kaiser, Martin E. (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Thome, Christian (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Ding, Lingjun (Institute of Neurobiology, University of Tübingen, Tübingen, Germany.) |
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Rozov, Andrei (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Klumpp, Matthias (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Stevens, Nikolas (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Stingl, Moritz (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Sackmann, Tina (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Lehmann, Nadja (Institute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.) |
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Draguhn, Andreas (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Burgalossi, Andrea (Institute of Neurobiology, University of Tübingen, Tübingen, Germany.) |
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Engelhardt, Maren (Institute of Anatomy and Cell Biology, Medical Faculty, Johannes Kepler University, Linz, Austria) |
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Both, Martin (Institute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany) |
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Grant Number: |
SFB 1134, projects A01 and A03 |
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Grant Number: |
BO 3512/2-1 |
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Grant Number: |
EN 1240/ 2-1 |
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Grant Number: |
BU 3126/2-1 |
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Grant Number: |
WBP Fellowship PN 458054460 |
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Distributor: |
heiDATA |
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Access Authority: |
Both, Martin |
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Holdings Information: |
https://doi.org/10.11588/data/JWLFFZ |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Mice, Hippocampus, Pyramidal cells, Axon-carrying Dendrite Cell, Ripple Oscillations, Perisomatic Inhibition, Information Processing |
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Abstract: |
Information processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition in conjunction with neuron-specific synaptic excitation. We report the selective recruitment of hippocampal pyramidal cells into patterned network activity. During ripple oscillations in awake mice, spiking is much more likely in cells in which the axon originates from a basal dendrite rather than from the soma. High-resolution recordings in vitro and computer modeling indicate that these spikes are elicited by synaptic input to the axon-carrying dendrite and thus escape perisomatic inhibition. Pyramidal cells with somatic axon origin can be activated during ripple oscillations by blocking their somatic inhibition. The recruitment of neurons into active ensembles is thus determined by axonal morphological features. |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Title: |
Alexander Hodapp, Martin E. Kaiser, Christian Thome, Lingjun Ding, Andrei Rozov, Matthias Klumpp, Nikolas Stevens, Moritz Stingl, Tina Sackmann, Nadja Lehmann, Andreas Draguhn, Andrea Burgalossi, Maren Engelhardt, Martin Both (2022) Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons, Science, in press. |
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Bibliographic Citation: |
Alexander Hodapp, Martin E. Kaiser, Christian Thome, Lingjun Ding, Andrei Rozov, Matthias Klumpp, Nikolas Stevens, Moritz Stingl, Tina Sackmann, Nadja Lehmann, Andreas Draguhn, Andrea Burgalossi, Maren Engelhardt, Martin Both (2022) Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons, Science, in press. |
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File Description--f7201 |
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File: Cell_Table_and_File_Allignment.tab |
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Notes: |
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