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Part 1: Document Description
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Citation |
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Title: |
A novel role for the cholinergic basal forebrain nucleus of Meynert in chronic pain via modulation of the prelimbic cortex |
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Identification Number: |
doi:10.11588/data/ET9G9X |
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Distributor: |
heiDATA |
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Date of Distribution: |
2022-07-19 |
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Version: |
1 |
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Bibliographic Citation: |
Oswald, Manfred Josef; Han, Yechao; Kuner, Rohini, 2022, "A novel role for the cholinergic basal forebrain nucleus of Meynert in chronic pain via modulation of the prelimbic cortex", https://doi.org/10.11588/data/ET9G9X, heiDATA, V1 |
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Citation |
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Title: |
A novel role for the cholinergic basal forebrain nucleus of Meynert in chronic pain via modulation of the prelimbic cortex |
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Alternative Title: |
Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behaviour via modulation of the prelimbic cortex |
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Identification Number: |
doi:10.11588/data/ET9G9X |
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Authoring Entity: |
Oswald, Manfred Josef (Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University) |
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Han, Yechao (Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University) |
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Kuner, Rohini (Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University) |
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Producer: |
Kuner, Rohini |
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Software used in Production: |
Cheetah |
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Software used in Production: |
Matlab |
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Software used in Production: |
Phy |
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Software used in Production: |
Excel |
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Grant Number: |
SFB 1158 |
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Distributor: |
heiDATA |
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Access Authority: |
Kuner, Rohini |
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Holdings Information: |
https://doi.org/10.11588/data/ET9G9X |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Mice, Basal Nucleus of Meynert, Chronic Pain, Nociception, Attention, Arousal, GABAergic neuron, Cholinergic Agent |
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Topic Classification: |
Neuroscience, Animal behavior |
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Abstract: |
This dataset contains all raw electrophysiology data and associated analysis procedures reported in Oswald et al. Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behaviour via modulation of the prelimbic cortex. Nat Comm (2022). Abstract: The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer’s and Parkinson’s dementias. Despite the crucial role of neocortical domains in pain perception, however, the NBM has not been studied in models of chronic pain. Here, using in vivo tetrode recordings in behaving mice, we report that beta and gamma oscillatory activity is evoked in the NBM by noxious stimuli and is facilitated at peak inflammatory pain-like behaviour. Optogenetic and chemogenetic cell-specific, reversible manipulations of NBM cholinergic-GABAergic neurons reveal their role in endogenous control of nociceptive hypersensitivity, which are manifest via projections to the prelimbic cortex, resulting in layer 5-mediated antinociception. Our data unravel the importance of the NBM in top-down control of neocortical processing of pain-like behaviour. |
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Date of Collection: |
2020-12-07-2020-12-24 |
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Kind of Data: |
Experimental data |
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Kind of Data: |
Electrophysiological recordings |
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Kind of Data: |
Video files |
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Kind of Data: |
Matlab analysis scripts |
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Notes: |
Two ReadMe files are included in the MATLAB scripts directory |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Title: |
Kuner R, Oswald MJ, Han Y, Li H, Marashli S, Oglou DN, Naser, P, Ojha B, Gan Z. A novel role for the cholinergic basal forebrain nucleus of Meynert in chronic pain via modulation of the prelimbic cortex. Research Square. |
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Identification Number: |
10.21203/rs.3.rs-1309454/v1 |
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Bibliographic Citation: |
Kuner R, Oswald MJ, Han Y, Li H, Marashli S, Oglou DN, Naser, P, Ojha B, Gan Z. A novel role for the cholinergic basal forebrain nucleus of Meynert in chronic pain via modulation of the prelimbic cortex. Research Square. |
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Label: |
BIN for Spike - Mouse NO1.zip |
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application/zip |
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BIN for Spike - Mouse NO2.zip |
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application/zip |
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BIN for Spike - Mouse NO3.zip |
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application/zip |
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BIN for Spike - Mouse NO4.zip |
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application/zip |
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BIN for Spike - Mouse NO5.zip |
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Notes: |
application/zip |
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MATLAB scripts.zip |
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Notes: |
application/zip |
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Mouse NO1.zip |
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Notes: |
application/zip |
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Mouse NO2.zip |
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Notes: |
application/zip |
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Mouse NO3.zip |
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Notes: |
application/zip |
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Mouse NO4.zip |
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application/zip |
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Mouse NO5.zip |
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Notes: |
application/zip |
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VonFreySegment.zip |
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Notes: |
application/zip |
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Label: |
VonFreySegmentNWMedian.zip |
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Notes: |
application/zip |