The contribution of drug import to the cost of tuberculosis treatment: a cost analysis of longer, shorter and short drug regimens for Karakalpakstan, Uzbekistan [Research Data] (doi:10.11588/data/LTTWSQ)

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The contribution of drug import to the cost of tuberculosis treatment: a cost analysis of longer, shorter and short drug regimens for Karakalpakstan, Uzbekistan [Research Data]

doi:10.11588/data/LTTWSQ

heiDATA

2024-04-18

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Kohler, Stefan; Sitali, Norman; Achar, Jay; Paul, Nicolas, 2024, "The contribution of drug import to the cost of tuberculosis treatment: a cost analysis of longer, shorter and short drug regimens for Karakalpakstan, Uzbekistan [Research Data]", https://doi.org/10.11588/data/LTTWSQ, heiDATA, V1

The contribution of drug import to the cost of tuberculosis treatment: a cost analysis of longer, shorter and short drug regimens for Karakalpakstan, Uzbekistan [Research Data]

doi:10.11588/data/LTTWSQ

Kohler, Stefan (Heidelberg University, Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health, Heidelberg, Germany and Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Social Medicine, Epidemiology and Health Economics, Berlin, Germany)

Sitali, Norman (Médecins Sans Frontières, Berlin, Germany)

Achar, Jay (Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden)

Paul, Nicolas (Heidelberg University, Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health, Heidelberg, Germany)

heiDATA

Kohler, Stefan

https://doi.org/10.11588/data/LTTWSQ

Medicine, Health and Life Sciences, costs and cost analysis, drug importation, drug procurement, import cost, supply and distribution, transportation costs, tuberculosis control, tuberculosis medicines, Uzbekistan

Tuberculosis (TB) programs depend on a continuous supply of large amounts of high-quality TB drugs. When TB programs procure TB drugs from international suppliers, such as the Global Drug Facility, they can incur import costs for international transport, customs clearance, and national transport. We assessed the drug costs and import costs of 18 longer (≥18 months), 10 shorter (9–12 months), and 8 short (≤6 months) drug regimens for drug-sensitive (DS) and multidrug-resistant (MDR)-TB treatment. Costs per regimen were estimated by multiplying recommended drug amounts with 2021 Global Drug Facility prices and drug import costs of a TB program in Karakalpakstan, Uzbekistan. The standard short-course treatment of DS-TB requires taking 730 fixed-dose combination tablets, which weigh 0.79 kg and cause an import cost of $4.19 (9.8% of the regimen’s drug cost of $43). A new 4-month DS-TB regimen requires taking 1358 tablets, which weigh 1.1 kg and cause an import cost of $6.07 (2.6% of the regimen’s drug cost of $233). MDR-TB regimens that last between 24 weeks and 20 months involve 546–9368 tablets and injections. The drugs for these MDR-TB regimens were estimated to weigh 0.42–96 kg and cause an import cost of $2.26–507 per drug regimen (0.29–11% of a regimen’s drug cost of $360–15,028). In a multivariable regression analysis, an additional treatment month increased the import cost of a drug regimen by $5.45 (95% CI: 1.65 to 9.26). Use of an injectable antibiotic in a regimen increased the import cost by $133 (95% CI: 47 to 219). The variable and potentially sizable import costs of TB regimens can affect the financial needs of TB programs. Drug regimens that are shorter and all-oral tend to reduce import costs compared to longer regimens and regimens including an injectable drug.

2021-

Kohler S, Sitali N, Achar J, Paul N. The contribution of drug import to the cost of tuberculosis treatment: a cost analysis of longer, shorter and short drug regimens for Karakalpakstan, Uzbekistan. PLOS Global Public Health 2022; 2: e0000567

10.1371/journal.pgph.0000567

Kohler S, Sitali N, Achar J, Paul N. The contribution of drug import to the cost of tuberculosis treatment: a cost analysis of longer, shorter and short drug regimens for Karakalpakstan, Uzbekistan. PLOS Global Public Health 2022; 2: e0000567

Kohler S, Sitali N, Achar J, Paul N. Costs and import costs of past, present, and future TB drug regimens: A case study for Karakalpakstan, Uzbekistan. Journal of Public Health 2022: article ID fdac124

10.1093/pubmed/fdac124

Kohler S, Sitali N, Achar J, Paul N. Costs and import costs of past, present, and future TB drug regimens: A case study for Karakalpakstan, Uzbekistan. Journal of Public Health 2022: article ID fdac124

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