Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy [Dataset] (doi:10.11588/data/04HPWW)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Document Description

Citation

Title:

Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy [Dataset]

Identification Number:

doi:10.11588/data/04HPWW

Distributor:

heiDATA

Date of Distribution:

2021-02-11

Version:

1

Bibliographic Citation:

Asan, Livia; Falfán-Melgoza, Claudia; Beretta, Carlo Antonio; Sack, Markus; Zheng, Lei; Weber-Fahr, Wolfgang; Kuner, Thomas; Knabbe, Johannes, 2021, "Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy [Dataset]", https://doi.org/10.11588/data/04HPWW, heiDATA, V1, UNF:6:t1jhJE4myjockvvIVpnP7A== [fileUNF]

Study Description

Citation

Title:

Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy [Dataset]

Identification Number:

doi:10.11588/data/04HPWW

Authoring Entity:

Asan, Livia (Institute for Anatomy and Cell Biology, Heidelberg University, Germany)

Falfán-Melgoza, Claudia (Translational Imaging Research Group, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, Germany)

Beretta, Carlo Antonio (Institute for Anatomy and Cell Biology, Heidelberg University, Germany)

Sack, Markus (Translational Imaging Research Group, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, Germany)

Zheng, Lei (Translational Imaging Research Group, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, Germany)

Weber-Fahr, Wolfgang (Translational Imaging Research Group, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, Germany)

Kuner, Thomas (Institute for Anatomy and Cell Biology, Heidelberg University, Germany)

Knabbe, Johannes (Institute for Anatomy and Cell Biology, Heidelberg University, Germany)

Producer:

Prof. Dr. Thomas Kuner

Software used in Production:

MATLAB, Fiji, ilastik

Grant Number:

SFB 1158

Distributor:

heiDATA

Access Authority:

Asan, Livia

Date of Deposit:

2019

Holdings Information:

https://doi.org/10.11588/data/04HPWW

Study Scope

Keywords:

Medicine, Health and Life Sciences, Microscopy, VBM, Voxel-based Morphometry, Correlative Neuroimaging

Topic Classification:

Neuroscience

Abstract:

This dataset accompanies the article of the same title in the journal Scientific Reports. It includes a) spreadsheets of data values for each plot in the main figures, b) all raw image data from Two-Photon in vivo microscopy (2pii) c) Custom code d) representative subsets of segmentation label images, coordinates of reidentified nuclei and corresponding magnetic resonance images from all timepoints of one animal (ID S8).

Methodology and Processing

Sources Statement

Data Access

Other Study Description Materials

Related Publications

Citation

Title:

Asan, L., Falfán-Melgoza, C., Beretta, C.A. et al. Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy. Sci Rep 11, 4234 (2021).

Identification Number:

https://doi.org/10.1038/s41598-021-83491-8

Bibliographic Citation:

Asan, L., Falfán-Melgoza, C., Beretta, C.A. et al. Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy. Sci Rep 11, 4234 (2021).

File Description--f4156

File: Figure 3 - source data 3.tab

  • Number of cases: 1120

  • No. of variables per record: 1

  • Type of File: text/tab-separated-values

Notes:

UNF:6:vrpiPQIngNC9iv7muzFjAw==

File Description--f4154

File: Figure 6 - source data 1.tab

  • Number of cases: 54

  • No. of variables per record: 4

  • Type of File: text/tab-separated-values

Notes:

UNF:6:NDIFW9dB88WxrxAxbaKKZA==

File Description--f4153

File: Figure 7 - source data 1.tab

  • Number of cases: 140

  • No. of variables per record: 4

  • Type of File: text/tab-separated-values

Notes:

UNF:6:/MHuX5ND39KkjVuL/IG90A==

File Description--f4152

File: Figure 8 - source data 1.tab

  • Number of cases: 80

  • No. of variables per record: 5

  • Type of File: text/tab-separated-values

Notes:

UNF:6:fMBoiE0tNmvnw2cdI4oUMQ==

File Description--f4155

File: Figure 8 - source data 2.tab

  • Number of cases: 21

  • No. of variables per record: 4

  • Type of File: text/tab-separated-values

Notes:

UNF:6:E2tbDYgEEg6l9aGGC2qO4w==

Variable Description

List of Variables:

Variables

AnimalNr; Timepoint; Atlas Roi; Side; GMVChange Percent

f4156 Location:

Variable Format: character

Notes: UNF:6:vrpiPQIngNC9iv7muzFjAw==

AnimalNr

f4154 Location:

Summary Statistics: Mean 4.777777777777777; Valid 54.0; StDev 2.3685571331681574; Max. 8.0; Min. 1.0

Variable Format: numeric

Notes: UNF:6:3ewIWvFOZWArKJpV64rN6w==

Timepoint

f4154 Location:

Summary Statistics: Min. 1.0; StDev 0.8241633836921342; Valid 54.0; Max. 3.0; Mean 2.0

Variable Format: numeric

Notes: UNF:6:G5iYb5yDNVKl6mugz97r9g==

Position

f4154 Location:

Summary Statistics: StDev 1.6416359381602001; Valid 54.0; Mean 3.7222222222222223; Max. 6.0; Min. 1.0

Variable Format: numeric

Notes: UNF:6:WD/RR0lUONWC/Il8R/+ejw==

ConvexHullvolume

f4154 Location:

Summary Statistics: Min. 3.0568219690624E7; Valid 54.0; Max. 1.20650000762651E8; StDev 2.616817956764479E7; Mean 7.864423260119674E7

Variable Format: numeric

Notes: UNF:6:XlgR6emcgEMuOjFuup1tyg==

AnimalNr

f4153 Location:

Summary Statistics: Max. 10.0; Mean 5.157142857142862; Min. 1.0; Valid 140.0; StDev 2.598481650102582

Variable Format: numeric

Notes: UNF:6:D+mj6fIgR8Ylups/2ae/1Q==

Timepoint

f4153 Location:

Summary Statistics: StDev 0.8070539473901018; Valid 140.0; Min. 1.0; Max. 3.0; Mean 1.8214285714285716

Variable Format: numeric

Notes: UNF:6:fNu+Si4cDuD/LBI4ZvtzKQ==

Position

f4153 Location:

Summary Statistics: Valid 140.0; Min. 1.0; StDev 1.6881638620338608; Mean 3.5785714285714283; Max. 6.0

Variable Format: numeric

Notes: UNF:6:HTm/du0Rf0EMKYeN5fNmgA==

NucleusCount

f4153 Location:

Summary Statistics: Max. 33868.0; Min. 8765.0; Valid 140.0; StDev 4773.522989931645; Mean 19310.664285714287;

Variable Format: numeric

Notes: UNF:6:6xZS5IksGQO3+MtZb5Strg==

AnimalNr

f4152 Location:

Summary Statistics: Max. 9.0; StDev 2.336285052835221; Mean 4.900000000000001; Valid 80.0; Min. 1.0;

Variable Format: numeric

Notes: UNF:6:QLcIKm3JWshQA/FSRbb10A==

Timepoint

f4152 Location:

Summary Statistics: Max. 3.0; StDev 0.49920823386588253; Valid 80.0; Min. 2.0; Mean 2.4375

Variable Format: numeric

Notes: UNF:6:wfoErqnoMjYb+hWkJljSSg==

Position

f4152 Location:

Summary Statistics: Max. 6.0; StDev 1.67062294149764; Min. 1.0; Valid 80.0; Mean 3.6375;

Variable Format: numeric

Notes: UNF:6:CMBgGKomaKp6P6q8Yr9Vfg==

Fractionoflargestnucleiinwholestack

f4152 Location:

Summary Statistics: StDev 14.500492139729316; Max. 144.829895422088; Mean 98.29771973336548; Valid 80.0; Min. 66.9483027760061

Variable Format: numeric

Notes: UNF:6:FC8GxR8EAsMWIMLifqDZNA==

GMVchange

f4152 Location:

Summary Statistics: Min. 97.5393483; StDev 0.5050330913222685; Max. 100.254377; Mean 99.78682065189874; Valid 79.0;

Variable Format: numeric

Notes: UNF:6:VTiYojTYgXnK1Gug6ZdOYQ==

LinearMixedModelstoexplainJDinMRImasks;AnimalIDasrandomeffect

f4155 Location:

Variable Format: character

Notes: UNF:6:ygIcq2ECMyosLo5zltxfAg==

B

f4155 Location:

Variable Format: character

Notes: UNF:6:8daGNHl1z6UO7X8GxsjVzA==

C

f4155 Location:

Variable Format: character

Notes: UNF:6:jR6cr4ZbI2VTInyK2nO4JA==

D

f4155 Location:

Variable Format: character

Notes: UNF:6:ebD+/WljCKhmwJm7+eyFFQ==

Other Study-Related Materials

Label:

CustomCode.zip

Notes:

application/zip

Other Study-Related Materials

Label:

RawImage_2Pii_S8_12weeks_position2.tif

Text:

Notes:

image/tiff

Other Study-Related Materials

Label:

RawImage_2Pii_S8_1week_position2.tif

Text:

Notes:

image/tiff

Other Study-Related Materials

Label:

RawImage_2Pii_S8_baseline_position2.tif

Text:

Notes:

image/tiff

Other Study-Related Materials

Label:

ReidentifiedNuclei_CenterCoordinates_S8_AllTimepoints.zip

Notes:

application/zip

Other Study-Related Materials

Label:

SegmentationLabels_S8_12weeks_position2.tif

Notes:

image/tiff

Other Study-Related Materials

Label:

SegmentationLabels_S8_1week_position2.tif

Text:

Notes:

image/tiff

Other Study-Related Materials

Label:

SegmentationLabels_S8_baseline_position2.tif

Text:

Notes:

image/tiff

Other Study-Related Materials

Label:

T2RARE_MRI_S8_12weeks.dcm

Notes:

application/dicom

Other Study-Related Materials

Label:

T2RARE_MRI_S8_1week.dcm

Notes:

application/dicom

Other Study-Related Materials

Label:

T2RARE_MRI_S8_baseline.dcm

Notes:

application/dicom

Other Study-Related Materials

Label:

12weeks_2Pii_part1.zip

Notes:

application/zip

Other Study-Related Materials

Label:

12weeks_2Pii_part10.zip

Notes:

application/zip

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Label:

12weeks_2Pii_part3.zip

Notes:

application/zip

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Label:

12weeks_2Pii_part4.zip

Notes:

application/zip

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Label:

12weeks_2Pii_part5.zip

Notes:

application/zip

Other Study-Related Materials

Label:

12weeks_2Pii_part6.zip

Notes:

application/zip

Other Study-Related Materials

Label:

12weeks_2Pii_part7.zip

Notes:

application/zip

Other Study-Related Materials

Label:

12weeks_2Pii_part8.zip

Notes:

application/zip

Other Study-Related Materials

Label:

12weeks_2Pii_part9.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part1.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part10.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part2.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part3.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part4.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part5.zip

Notes:

application/zip

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Label:

1week_2Pii_part6.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part7.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part8.zip

Notes:

application/zip

Other Study-Related Materials

Label:

1week_2Pii_part9.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part1.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part10.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part2.zip

Notes:

application/zip

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Label:

Baseline_2Pii_part3.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part4.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part5.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part6.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part7.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part8.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_part9.zip

Notes:

application/zip

Other Study-Related Materials

Label:

Baseline_2Pii_partS1.zip

Notes:

application/zip